0000000001109244

AUTHOR

Didier Mazel

showing 3 related works from this author

The emergence of Vibrio pathogens in Europe : ecology, evolution, and pathogenesis (Paris, 11-12th March 2015)

2015

Global change has caused a worldwide increase in reports of Vibrio-associated diseases with ecosystem-wide impacts on humans and marine animals. In Europe, higher prevalence of human infections followed regional climatic trends with outbreaks occurring during episodes of unusually warm weather. Similar patterns were also observed in Vibrio-associated diseases affecting marine organisms such as fish, bivalves and corals. Basic knowledge is still lacking on the ecology and evolutionary biology of these bacteria as well as on their virulence mechanisms. Current limitations in experimental systems to study infection and the lack of diagnostic tools still prevent a better understanding of Vibrio…

Cell- och molekylärbiologilcsh:QR1-502NetworkPACIFIC OYSTERS[ SDV.MP.BAC ] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriologyglobal warminghuman healthgenome plasticityHORIZONTAL GENE-TRANSFERlcsh:Microbiologyeuropean network/dk/atira/pure/sustainabledevelopmentgoals/zero_hungerOYSTERS CRASSOSTREA-GIGASApplied researchFood securitybiologyEcologyGenome plasticityMARINE PHOTOBACTERIUMHuman health risksaquacultureSECRETION SYSTEMPerspective/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingVibrio-host interactionVIRULENCE FACTORSMicrobiology (medical)570Ecology (disciplines)Social issuesMicrobiology/dk/atira/pure/sustainabledevelopmentgoals/life_below_waterSDG 3 - Good Health and Well-being[SDV.BID.EVO] Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE]14. Life underwaterSDG 14 - Life Below WaterSDG 2 - Zero HungerBacterial diseaseanimal modelGlobal warmingOutbreakBiology and Life Sciencesgenome asticityD-AMINO ACIDSAnimal model; Aquaculture; Bacterial disease; Biotic-abiotic interactions; Genome plasticity; Global warming; Human health; Network; Vibrio-host interaction; Microbiology; Microbiology (medical)interactionsbiology.organism_classificationCLINICAL SOURCES[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriologybacterial diseaseBiotic-abiotic interactionsVibrioDAMSELAE SUBSP DAMSELAE13. Climate actionnetworksCell and Molecular BiologyPHOTOBACTERIUM-DAMSELAE
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Enhanced emergence of antibiotic-resistant pathogenic bacteria after in vitro induction with cancer chemotherapy drugs.

2019

International audience; BACKGROUND:Infections with antibiotic-resistant pathogens in cancer patients are a leading cause of mortality. Cancer patients are treated with compounds that can damage bacterial DNA, potentially triggering the SOS response, which in turn enhances the bacterial mutation rate. Antibiotic resistance readily occurs after mutation of bacterial core genes. Thus, we tested whether cancer chemotherapy drugs enhance the emergence of resistant mutants in commensal bacteria.METHODS:Induction of the SOS response was tested after the incubation of Escherichia coli biosensors with 39 chemotherapeutic drugs at therapeutic concentrations. The mutation frequency was assessed after …

0301 basic medicineMicrobiology (medical)Staphylococcus aureusmedicine.drug_class030106 microbiologyAntibioticsAntineoplastic AgentsDrug resistanceMicrobial Sensitivity TestsBiologymedicine.disease_causeMicrobiology03 medical and health sciencesSOS Response (Genetics)0302 clinical medicineAntibiotic resistanceDrug Resistance BacterialEnterobacter cloacaemedicineHumansPharmacology (medical)030212 general & internal medicineMutation frequencySOS responseSOS Response GeneticsPharmacologyPathogenic bacteriaChemotherapy regimen3. Good healthAnti-Bacterial Agents[SDV.MP]Life Sciences [q-bio]/Microbiology and ParasitologyInfectious DiseasesPseudomonas aeruginosaThe Journal of antimicrobial chemotherapy
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The emergence of Vibrio pathogens in Europe: ecology, evolution, and pathogenesis

2015

Global change has caused a worldwide increase in reports of Vibrio-associated diseases with ecosystem-wide impacts on humans and marine animals. In Europe, higher prevalence of human infections followed regional climatic trends with outbreaks occurring during episodes of unusually warm weather. Similar patterns were also observed in Vibrio-associated diseases affecting marine organisms such as fish, bivalves and corals. Basic knowledge is still lacking on the ecology and evolutionary biology of these bacteria as well as on their virulence mechanisms. Current limitations in experimental systems to study infection and the lack of diagnostic tools still prevent a better understanding of Vibrio…

Canvi mediambiental globalBacteris patògensMicrobiologia
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