Using discourse segmentation to account for the polyfunctionality of discourse markers:The case of well
Abstract A large number of studies describe the many different functions of polyfunctional discourse markers like well in different contexts and from different theoretical perspectives. In the current paper, we propose to systematize the many different uses identified based on their position with respect to the discourse units they are associated with. Not only can previous findings on well be integrated into a single coherent representation of its uses and functions, but the positions with respect to the discourse units can also be associated with specific functions, thus shedding light on how the polyfunctionality of well is brought about.
Sirtuin-6-dependent genetic and epigenetic alterations are associated with poor clinical outcome in hepatocellular carcinoma patients
Sirtuin 6 (SIRT6) is a member of the sirtuin family of NAD+–dependent deacetylases. Genetic deletion of Sirt6 in mice results in a severe degenerative phenotype with impaired liver function and premature death. The role of SIRT6 in development and progression of hepatocellular carcinoma is currently unknown. We first investigated SIRT6 expression in 153 primary human liver cancers and in normal and cirrhotic livers using microarray analysis. SIRT6 was significantly down-regulated in both cirrhotic livers and cancer. A Sirt6 knockout (KO) gene expression signature was generated from primary hepatoctyes isolated from 3-week-old Sirt6-deficient animals. Sirt6-deficient hepatocytes showed up-re…