0000000001116680
AUTHOR
Harald Fritz
Evolution Over Time of Ventilatory Management and Outcome of Patients With Neurologic Disease
OBJECTIVES: To describe the changes in ventilator management over time in patients with neurologic disease at ICU admission and to estimate factors associated with 28-day hospital mortality. DESIGN: Secondary analysis of three prospective, observational, multicenter studies. SETTING: Cohort studies conducted in 2004, 2010, and 2016. PATIENTS: Adult patients who received mechanical ventilation for more than 12 hours. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Among the 20,929 patients enrolled, we included 4,152 (20%) mechanically ventilated patients due to different neurologic diseases. Hemorrhagic stroke and brain trauma were the most common pathologies associated with the need fo…
Tryptophan immunoadsorption during pregnancy and breastfeeding in patients with acute relapse of multiple sclerosis and neuromyelitis optica.
Background: Up to every fourth woman with multiple sclerosis (MS) or neuromyelitis optica spectrum disorder (NMOSD) suffers a clinically relevant relapse during pregnancy. High doses of steroids bear some serious risks, especially within the first trimester of pregnancy. Immunoadsorption (IA) is an effective and more selective treatment option in disabling MS relapse than plasma exchange. Data on the use of IA during pregnancy and breastfeeding are scarce. Methods: In this retrospective multicenter study, we analyzed the safety and efficacy of IA treatment in acute relapses during pregnancy or breastfeeding. The primary outcome parameter - change of acute relapse-related disability after IA…
SHRIMP U–Pb zircon and Sm–Nd garnet ages from the granulite-facies basement of SE Kenya: evidence for Neoproterozoic polycyclic assembly of the Mozambique Belt
The Taita Hills–Galana River region is a key area to demonstrate the polycyclic nature of the Mozambique Belt in SE Kenya. On the basis of petrological and tectonic data, this area is composed of two different granulite-facies terranes, which are separated by the 20–30 km wide Galana Shear Zone. The Taita Hills and adjoining Sagala Hills exhibit a metamorphic overprint at 630–645 Ma, similar to areas in Tanzania. An emplacement age for the magmatic precursor rocks of 850–960 Ma was derived from zircon cores. Sm–Nd garnet–whole-rock analyses give an age of 585 Ma, interpreted as the cooling age after 630–645 Ma metamorphism. Nd crustal residence ages are between 1000 and 1500 Ma. The Galana …