0000000001117868

AUTHOR

Valerie Tikhonoff

0000-0001-7846-0101

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Serum uric acid levels threshold for mortality in diabetic individuals: The URic acid Right for heArt Health (URRAH) project

2022

Background and aim: The URRAH (URic acid Right for heArt Health) Study has identified cut-off values of serum uric acid (SUA) predictive of total mortality at 4.7 mg/dl, and cardiovascular (CV) mortality at 5.6 mg/dl. Our aim was to validate these SUA thresholds in people with diabetes. Methods and results: The URRAH subpopulation of people with diabetes was studied. All-cause and CV deaths were evaluated at the end of follow-up. A total of 2570 diabetic subjects were studied. During a median follow-up of 107 months, 744 deaths occurred. In the multivariate Cox regression analyses adjusted for several confounders, subjects with SUA ≥5.6 mg/dl had higher risk of total (HR: 1.23, 95%CI: 1.04-…

Diabetes mellituNutrition and DieteticsSettore MED/09 - Medicina InternaCardiovascular mortalitySerum uric acid Cardiovascular mortality All-cause mortality Diabetes mellitus Hyperuricemia Diagnostic thresholdsEndocrinology Diabetes and MetabolismMedicine (miscellaneous)HyperuricemiaAll-cause mortalityUric AcidDiagnostic thresholdsall-cause mortality; cardiovascular mortality; diabetes mellitus; diagnostic thresholds; hyperuricemia; serum uric acid; humans; risk factors; uric acid; diabetes mellitus; hyperuricemiaDiagnostic thresholdDiabetes mellitusSerum uric acidRisk FactorsAll-cause mortality; Cardiovascular mortality; Diabetes mellitus; Diagnostic thresholds; Hyperuricemia; Serum uric acidHumansCardiology and Cardiovascular Medicine
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