0000000001119366
AUTHOR
Sally Dawson
Genome-wide association analysis on normal hearing function identifies PCDH20 and SLC28A3 as candidates for hearing function and loss.
Hearing loss and individual differences in normal hearing both have a substantial genetic basis. Although many new genes contributing to deafness have been identified, very little is known about genes/variants modulating the normal range of hearing ability. To fill this gap, we performed a two-stage meta-analysis on hearing thresholds (tested at 0.25, 0.5, 1, 2, 4, 8 kHz) and on pure-tone averages (low-, medium-and high-frequency thresholds grouped) in several isolated populations from Italy and Central Asia (total N = 2636). Here, we detected two genome-wide significant loci close to PCDH20 and SLC28A3 (top hits: rs78043697, P = 4.71E-10 and rs7032430, P = 2.39E-09, respectively). For both…
The Hunt for New Physics at the Large Hadron Collider
233 páginas.-- AHEP Group: et al..-- El Pdf del artículo es la versión pre-print: arXiv.1001.2693v1.-- Trabajo presentado al "The International Workshop on Beyond the Standard Model Physics and LHC Signatures (BSM-LHC) celebrado en Boston (USA) del 2 al 4 de junio de 2009.