COMPARATIVE PROTEOMIC PROFILING OF NORMAL AND BREAST CANCER CELLS UNDER HYPOXIC CONDITIONS

influences emanating from the tissue microenvironment, such as cell-cell and cell-matrix interactions and other local pathophysiologic conditions as hypoxia. However the hypoxic effect may be different according to the cell conditions. For example, the low concentration of tissue oxygen (pO2 <7 mmHg) may exert anti-proliferative effects on normal cells and may induce differentiation or apoptosis and necrosis. On the other contrary, tumour cells likely react to hypoxic stress with an adaptive process through modification of gene expression that may confer an aggressive phenotype to cells, promoting their local and distant spread [1]. In general it is believed that hypoxic microenvironments i…