Author: Claire Cherbuy

0000000001135322

AUTHOR

Claire Cherbuy

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Age-Related Changes in the Gut Microbiota Modify Brain Lipid Composition

2020

PMCID: PMC6970973; International audience; Understanding the molecular mechanisms underlying the changes observed during aging is a prerequisite to design strategies to prevent age-related diseases. Aging is associated with metabolic changes, including alteration in the brain lipid metabolism. These alterations may contribute to the development of pathophysiological conditions. Modifications in the gut microbiota composition are also observed during aging. As communication axes exist between the gut microbiota and the brain and knowing that microbiota influences the host metabolism, we speculated on whether age-associated modifications in the gut microbiota could be involved in the lipid ch…

Fatty Acid DesaturasesMale0301 basic medicinelcsh:QR1-502Gene ExpressionGut floralcsh:MicrobiologyFatty Acids MonounsaturatedMiceCellular and Infection MicrobiologyAging brain[SDV.BDD]Life Sciences [q-bio]/Development BiologyOriginal Researchchemistry.chemical_classificationFatty AcidsAge FactorsBrainLipidscortexInfectious DiseasesFatty Acids Unsaturated[SDV.IMM]Life Sciences [q-bio]/Immunologylipids (amino acids peptides and proteins)SphingomyelinStearoyl-CoA DesaturasePolyunsaturated fatty acidMicrobiology (medical)medicine.medical_specialty[SDV.IMM] Life Sciences [q-bio]/ImmunologyFatty Acid ElongasesFADS1FADS2030106 microbiologyImmunologyBiologyliverdigestive systemMicrobiology03 medical and health scienceslipidInternal medicine[SDV.BDD] Life Sciences [q-bio]/Development BiologymedicinemicrobiotaAnimalsGerm-Free LifephospholipidagingFatty acidcholesterolLipid Metabolismbiology.organism_classificationGastrointestinal MicrobiomeTransplantation[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition030104 developmental biologyEndocrinologychemistryfatty acid[SDV.AEN]Life Sciences [q-bio]/Food and NutritionFrontiers in Cellular and Infection Microbiology

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