0000000001142940
AUTHOR
Isabel Aparici-espert
A Combined Experimental and Theoretical Approach to the Photogeneration of 5,6-Dihydropyrimidin-5-yl Radicals in Nonaqueous Media
The chemical fate of radical intermediates is relevant to understand the biological effects of radiation and to explain formation of DNA lesions. A direct approach to selectively generate the putative reactive intermediates is based on the irradiation of photolabile precursors. But, to date, radical formation and reactivity have only been studied in aqueous media, which do not completely mimic the micro environment provided by the DNA structure and its complexes with proteins. Thus, it is also important to evaluate the photogeneration of nucleoside-based radicals in nonaqueous media. The attention here is focused on the independent generation of 5,6-dihydropyrimidin-5-yl radicals in organic…
CCDC 1444537: Experimental Crystal Structure Determination
Related Article: Isabel Aparici-Espert, Antonio Francés-Monerris, Gemma M. Rodríguez-Muñiz, Daniel Roca-Sanjuán, Virginie Lhiaubet-Vallet, Miguel A. Miranda|2016|J.Org.Chem.|81|4031|doi:10.1021/acs.joc.6b00314