In vitro modulation of cytokines by pathogens and probiotics on the skin of Gilthead Seabream (Sparus aurata)

Gilthead seabream (Sparus aurata) is the only species of the Sparidae family currently bred on a large scale. As one of the most important species on Mediterranean aquaculture. For this main reason, the knowledge of its immune system and their alterations it is crucial to avoid economic losses worldwide. Fish are in intimate contact with their environment and defending itself by a complex system of innate defence mechanisms, that is divided into physical barriers, cellular and humoral components. The skin as a physical barrier seems to be central to protection from pathogens such as Photobacterium damselae ssp. piscicida. Probiotics are microorganisms (usually bacteria) that promote differe…