0000000001153652

AUTHOR

Melanie L. Stephens

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Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages

2020

Background: During early stages, patients with neurodegenerative diseases (NDG) often present with depressive symptoms. However, because depression is a heterogeneous disorder, more precise delineation of the specific depressive symptom profiles that arise early in distinct NDG syndromes is necessary to enhance patient diagnosis and care. Methods and Findings: Five-hundred and sixty four participants self-reported their depressive symptoms using the Geriatric Depression Scale (GDS), including 111 healthy older control subjects (NC) and 453 patients diagnosed with one of six NDGs who were at the mild stage of disease (CDR® Dementia Staging Instrument ≤ 1) [186 Alzheimer's disease (AD), 76 be…

PediatricsAgingDiseaseNeurodegenerativeAlzheimer's Diseasefrontotemporal dementialcsh:RC346-429Primary progressive aphasia0302 clinical medicineneurodegenerative diseasehopelessnessworry2.1 Biological and endogenous factorsPsychology030212 general & internal medicineAetiologyDepression (differential diagnoses)Original ResearchdysphoraDepressionAlzheimer'sFrontotemporal Dementia (FTD)Mental HealthNeurologyNeurologicaldepressionGeriatric Depression Scalemedicine.symptomFrontotemporal dementiamedicine.medical_specialtyClinical SciencesDysphoriaProgressive supranuclear palsy7.3 Management and decision making03 medical and health sciencesRare DiseasesClinical ResearchBehavioral and Social SciencemedicineAcquired Cognitive ImpairmentDementialcsh:Neurology. Diseases of the nervous systembusiness.industryNeurosciencesAlzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)progressive supranuclear palsymedicine.diseaseBrain DisordersGood Health and Well BeingDementiaNeurology (clinical)Management of diseases and conditionsbusiness030217 neurology & neurosurgeryFrontiers in Neurology
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