Author: Lucia Quintero

0000000001157254

AUTHOR

Lucia Quintero

Organocatalytic Enantioselective Synthesis of α-Hydroxyketones through a Friedel−Crafts Reaction of Naphthols and Activated Phenols with Aryl- and Alkylglyoxal Hydrates

[EN] An efficient organocatalytic asymmetric synthesis of alpha-hydroxyketones has been developed. Quinine-derived thiourea catalyzed the enantioselective Friedel Crafts alkylation of naphthols and activated phenols with aryl- and alkylglyoxal hydrates, providing the corresponding chiral alpha-hydroxyketones with high yields (up to 97%) and excellent enantioselectivities (up to 99% ee).

research product

CCDC 1505242: Experimental Crystal Structure Determination

Related Article: Carlos Vila, Lucia Quintero, Gonzalo Blay, M. Carmen Muñoz, José R. Pedro|2016|Org.Lett.|18|5652|doi:10.1021/acs.orglett.6b02893

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