0000000001157562

AUTHOR

Gyula Goebel

showing 1 related works from this author

Low SPINK5 expression in chronic rhinosinusitis

2012

Objectives/Hypothesis: Chronic rhinosinusitis (CRS) is a multifactorial disease that probably arises as a result of genetic diversity and environmental factors. SPINK5 is a serine protease inhibitor, which is supposed to be an important regulator of epithelial barrier maintenance. The role of SPINK5 polymorphisms and expression in CRS, especially in individuals with aspirin intolerance, is unclear. Study Design: SPINK5 single-nucleotide polymorphisms (SNPs) and SPINK5 expression levels were correlated with CRS without (CRSsNP) and with nasal polyps (CRSwNP), aspirin intolerance, asthma, and allergies. Methods: One hundred four nasal tissue samples, 15 from patients with CRSsNP, 59 from pati…

AdultMalePathologymedicine.medical_specialtyAllergyAdolescentGenotypeProteinase Inhibitory Proteins SecretorySingle-nucleotide polymorphismPolymerase Chain ReactionPolymorphism Single NucleotideSensitivity and SpecificitySampling Studieslaw.inventionDrug HypersensitivityTissue Culture TechniquesYoung AdultNasal PolypsReference ValueslawGenotypemedicineHumansSNPNasal polypsRNA MessengerSinusitisPolymerase chain reactionAgedRhinitisAsthmaAged 80 and overAspirinbusiness.industryMiddle Agedmedicine.diseaseAsthmaPathophysiologyNasal MucosaGene Expression RegulationOtorhinolaryngologyChronic DiseaseImmunologySerine Peptidase Inhibitor Kazal-Type 5FemalebusinessThe Laryngoscope
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