0000000001157939

AUTHOR

Jean W. Hsu

0000-0002-5666-3132

showing 1 related works from this author

Glutathione metabolism in type 2 diabetes and its relationship with microvascular complications and glycemia

2018

Aims/hypotheses We hypothesized that there is decreased synthesis of glutathione (GSH) in type 2 diabetes (T2DM) especially in the presence of microvascular complications, and this is dependent on the degree of hyperglycemia. Methods In this case-control study, we recruited 16 patients with T2DM (7 without and 9 with microvascular complications), and 8 age- and sex-matched non-diabetic controls. We measured GSH synthesis rate using an infusion of [2H2]-glycine as isotopic tracer and collection of blood samples for liquid chromatography mass spectrometric analysis. Results Compared to the controls, T2DM patients had lower erythrocyte GSH concentrations (0.90 ± 0.42 vs. 0.35 ± 0.30 mmol/L; P …

Blood GlucoseMale0301 basic medicinelcsh:MedicineType 2 diabetesmedicine.disease_causeBiochemistrychemistry.chemical_compoundEndocrinology0302 clinical medicineGlucose MetabolismAnimal CellsRed Blood CellsMedicine and Health SciencesDiabetes diagnosis and managementMedicineAmino Acidslcsh:ScienceMultidisciplinaryOrganic CompoundsMiddle AgedGlutathioneMass spectrometricType 2 DiabetesChemistryPhysical SciencesCarbohydrate MetabolismFemaleCellular TypesResearch ArticleAdultGlutathione metabolismmedicine.medical_specialtyHbA1cEndocrine DisordersGlycine030209 endocrinology & metabolism03 medical and health sciencesDiabetes mellitusInternal medicineMoleDiabetes MellitusHumansHemoglobinBlood Cellsbusiness.industrylcsh:ROrganic ChemistryChemical CompoundsCase-control studyBiology and Life SciencesProteinsCell BiologyGlutathionemedicine.diseaseDiagnostic medicineOxidative StressMetabolism030104 developmental biologyEndocrinologyAliphatic Amino AcidsDiabetes Mellitus Type 2chemistryMetabolic DisordersCase-Control StudiesMicrovesselslcsh:QPeptidesbusinessDiabetic AngiopathiesOxidative stressPLOS ONE
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