0000000001158138
AUTHOR
Rubén Sánchez-garcía
Enantioselective Synthesis of 2-Amino-1,1-diarylalkanes Bearing a Carbocyclic Ring Substituted Indole through Asymmetric Catalytic Reaction of Hydroxyindoles with Nitroalkenes
[EN] An asymmetric catalytic reaction of hydroxyindoles with nitroalkenes leading to the Friedel-Crafts alkylation in the carbocyclic ring of indole is presented. The method is based on the activating/directing effects of the hydroxy group situated in the carbocyclic ring of the indole providing nitroalkylated indoles functionalizated at the C-4, C-5, and C-7 positions with high yield, regio-, and enantioselectivity. The optically enriched nitroalkanes were transformed efficiently in optically enriched 2-amino-1,1-diarylalkanes bearing a carbocyclic ring substituted indole.
CCDC 1821100: Experimental Crystal Structure Determination
Related Article: Carlos Vila, Jaume Rostoll-Berenguer, Rubén Sánchez-García, Gonzalo Blay, Isabel Fernández, M. Carmen Muñoz, and José R. Pedro|2018|J.Org.Chem.|83|6397|doi:10.1021/acs.joc.8b00612
CCDC 1821099: Experimental Crystal Structure Determination
Related Article: Carlos Vila, Jaume Rostoll-Berenguer, Rubén Sánchez-García, Gonzalo Blay, Isabel Fernández, M. Carmen Muñoz, and José R. Pedro|2018|J.Org.Chem.|83|6397|doi:10.1021/acs.joc.8b00612