0000000001159709

AUTHOR

Beibei Jiang

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Cis-epistasis at the LPA locus and risk of cardiovascular diseases.

2022

AIMS Coronary artery disease (CAD) has a strong genetic predisposition. However, despite substantial discoveries made by genome-wide association studies (GWAS), a large proportion of heritability awaits identification. Non-additive genetic-effects might be responsible for part of the unaccounted genetic variance. Here we attempted a proof-of-concept study to identify non-additive genetic effects, namely epistatic interactions, associated with CAD. METHODS AND RESULTS We tested for epistatic interactions in ten CAD case-control studies and UK Biobank with focus on 8,068 SNPs at 56 loci with known associations with CAD risk. We identified a SNP pair located in cis at the LPA locus, rs1800769 …

GeneticsPhysiologyMedizinEpistasis GeneticSingle-nucleotide polymorphismLocus (genetics)Genome-wide association studyCoronary Artery DiseaseBiologyPolymorphism Single NucleotideMinor allele frequencyCardiovascular DiseasesStatistical Genetics ; Epistasis ; Coronary Artery Diseases ; LpaPhysiology (medical)Genetic predispositionHumansAdditive genetic effectsEpistasisGenetic Predisposition to DiseaseCardiology and Cardiovascular MedicineGenome-Wide Association StudyLipoprotein(a)Genetic association
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