Thermal aggregation of glycated Bovine Serum Albumin

Aggregation of albumin: influence of the protein glycation

Free radicals are a normal component of cellular oxygen metabolism in mammals. However, free radical-associated damage is an important factor in many pathological processes. Aggregation, glycation and oxidative damage cause protein modifications, frequently observed in numerous diseases. Albumin represents the most abundant circulating protein. Many epidemiological studies have established an inverse relationship between the level of serum albumin and the risk of death. Albumin is involved in several biological functions, including the regulation of oncotic pressure, and the binding and transport of many molecules. In addition, albumin displays potent antioxidant and free radical scavenging…