The late Carnian Rhaetian Succession at Pizzo Mondello (Sicani Mountains).

The optimal dose of ribavirin for chronic hepatitis C: From literature evidence to clinical practice: The optimal dose of ribavirin for chronic hepatitis C.

Approximately 170 million people worldwide are chronically infected by hepatitis C virus (HCV), which can result in progressive hepatic injury and fibrosis, culminating in cirrhosis and end-stage liver disease. The benchmark therapy for untreated HCV patients is a combination of pegylated interferon-alpha (PEG-IFN) and ribavirin (RBV). Several studies have suggested several potential new approaches to improve HCV therapy-optimization of the dose and duration of RBV therapy, accompanied by careful clinical management, is crucial in ensuring the greatest likelihood of a long response to therapy. RBV causes serious side effects, but in clinical practice, there are no alternatives for the treat…

The Carnian/Norian boundary interval at Pizzo Mondello (Sicani Mountains, Sicily) and its bearing for the definition of the GSSP of the Norian Stage

We present the magnetostratigraphy and stable isotope stratigraphy from an expanded (~430-m-thick) Upper Triassic marine limestone section at Pizzo Mondello, Sicily, and review published biostratigraphic information that can be used to defi ne the location of the conodont Carnian-Norian and Norian-Rhaetian boundaries in this section. Pizzo Mondello offers good potential for magneto-stratigraphic correlation of marine biostrati-graphic and chemostratigraphic data with the continental Newark astrochronological polarity time scale (APTS) for development of an integrated Late Triassic time scale. The relatively stable average values of δ18O centered on 0‰ are a strong indication that the Cherty …