L’exposition par des mélanges de perturbateurs endocriniens à faibles doses modifie la différenciation adipocytaire

National audience

Are taste preferences related to submandibular endocrine or exocrine secretions? A rodent study

National audience

CIME: An integrative and multidisciplinary PNR-PE project on Chronic Impact of ED Mixture Exposure at environmental low doses on Reproduction, Development and Behavior

CIME: An integrative and multidisciplinary PNR-PE project on Chronic Impact of ED Mixture Exposure at environmental low doses on Reproduction, Development and Behavior. Colloque PNR-PE

Oral homeostasis disruption by medical plasticizer component bisphenol A in adult male rats.

Objectives/Hypothesis Bisphenol A (BPA) is a synthetic estrogen-like chemical mimetic widely used in the manufacture of polycarbonate plastics and epoxy resins found in numerous consumer products including food packaging, medical devices, and dental sealants. Because it is recovered in fluids and it can reach high levels in saliva, this study aimed to evaluate its safety on oral homeostasis by examining its effects on salivary glands, mouth epithelium, water consumption, and salt preference, each parameter being estrogen sensitive. Study Design Randomized controlled trial involving rats. Methods A dose-response study was conducted in adult Wistar rats randomized into five groups (n = 12). B…

Relationship between endocrine disruptors and obesity with a focus on bisphenol A: a narrative review

International audience; Introduction: Scientific data suggest that early exposure to endocrine-disrupting chemicals (EDCs) affect -repro, -neuro, -metabolic systems, to which are added other notions such as mixtures, window and duration of exposure, trans-generational effects, and epigenetic mechanisms. Methods: In the present narrative review, we studied the relationship between exposure to EDCs with the appearance and development of obesity. Results: Exposure to EDCs like Bisphenol A during the early stages of development has been shown to lead to weight gain and obesity. EDCs can interfere with endocrine signaling, affect adipocytes differentiation and endocrine function and disrupt meta…

Low doses in vivo studies of dietary endocrine disruptor mixtures: Sexual dimorphism relevance of biological target for a trans-generational study in a rodent model

Low doses in vivo studies of dietary endocrine disruptor mixtures: Sexual dimorphism relevance of biological target for a trans-generational study in a rodent model. 1. international toxicology of mixtures conference

Bisphenol A from drinking water affects taste preferences and oral homeostasis in male rat

National audience

An integrative and multidisciplinary PNR-PE project for studying Chronic Impact of ED Mixture Exposures at environmental low doses on reproduction, development and behavior.

National audience

Tran generational effects of xeno-hormones mixtures on development and behaviour in rats

International audience

Effets trans-générationnel du Bisphénol A sur le comportement et le développement chez le rat

National audience

Études in vivo de mélanges de perturbateurs endocriniens alimentaires à faibles doses : analyse phénotypique de cibles biologiques et des conditions expérimentales pour une approche trans-générationnelle sur un modèle rat

National audience

Effects of oral Bisphenol A exposure on sweet preference and on submandibular salivary gland structure in male adult rat

La Revue de Gériatrie; Objectifs: Le Bisphénol A (BPA) est un œstrogéno-mimétique qui entre dans la fabrication de plastiques en polycarbonate et de résines époxy destinés entre autres à l'élaboration d'emballages alimentaires, de matériel médical et d'amalgames dentaires. Pouvant atteindre des taux élevés dans la salive, l'objectif de cette étude était de vérifier l'innocuité du BPA au niveau buccal en recherchant les effets sur les préférences gustatives et sur les glandes saliuaires, deux paramètres sensibles aux œstrogènes. Matériels et Méthodes: Une étude effet-dose a été réalisée sur des rats Wistar adultes répartis en 5 groupes (n=12). Le Bisphénol A a été administré pendant 6 semain…

Effets des Xéno-hormones sur la prise alimentaire et les préférences gustatives associées au comportement alimentaire chez le rat. Rapport d'activité mi-contrat de thèse

Effets trans-générationnel des xéno-hormones sur le comportement et le développement chez le rat

International audience

Exposition continue aux xéno-hormones à faibles doses chez le rat : effets multi-générationnels de mélanges sur les préférences gustatives, le comportement maternel, et le développement

During the last decade, the issue of health-related endocrine disruptors (ED) has been extended to the toxicity of mixtures. The objective of this study was to define the effects of lifelong exposure to ED mixtures, at low doses defined as "non-harmful" by the authorities. In this aim, the effects of mixtures combining genistein, vinclozolin and bisphenol A, have been investigated in the rat by using an integrative and multi-generational experimental approach which takes into account maternal behavior, feeding behavior and development. Our results show that these mixtures could: a) reduce maternal behavior, b) change taste preferences (sweet, salty), c) affect the development from the in ut…

Effets d’une exposition orale en Bisphenol A sur la préférence au salé et la structure de la glande sous-mandibulaire chez le rat mâle adulte

Effets d’une exposition orale en Bisphenol A sur la préférence au salé et la structure de la glande sous-mandibulaire chez le rat mâle adulte. Colloque PNR-PE

A multi-generational study on low-dose BPA exposure in Wistar rats: Effects on maternal behavior, flavor intake and development

Bisphenol A (BPA) is a common endocrine disruptor found as an environmental and food contaminant. It exerts both developmental and behavioral effects, mainly when exposure occurs in early life. The aim of this study was to determine the multi-generational effects of chronic, human-relevant low-dose exposure to BPA on development, maternal behavior and flavor preference in Wistar rats. BPA was orally administered at a daily dose of 5 mu g/kg body weight to FO pregnant dams from the first day of gestation (GD 1) until the last day of lactation (LD 21), and then to Fl offspring from weaning (PND 21) to adulthood (PND 100). F2 offspring were not exposed. Development and clinical signs of toxici…

Modification des préférences gustatives et de la plasticité structurale des glandes salivaires par une exposition chronique au bisphenol A chez le rat male adulte

Modification des préférences gustatives et de la plasticité structurale des glandes salivaires par une exposition chronique au bisphenol A chez le rat male adulte. colloque de la SFORL

Effects of BPA and Endocrine Disruptor Mixtures on development and taste preferences in the non-exposed F2 offspring Wistar rats. CIME project

Effects of BPA and Endocrine Disruptor Mixtures on development and taste preferences in the non-exposed F2 offspring Wistar rats. CIME project. Colloque PNR-PE

Lifelong exposure to low dose xeno-hormones in rats : multi-generational effects of xeno-hormone mixtures on taste preferences, maternal behavior, and development

During the last decade, the issue of health-related endocrine disruptors (ED) has been extended to the toxicity of mixtures. The objective of this study was to define the effects of lifelong exposure to ED mixtures, at low doses defined as "non-harmful" by the authorities. In this aim, the effects of mixtures combining genistein, vinclozolin and bisphenol A, have been investigated in the rat by using an integrative and multi-generational experimental approach which takes into account maternal behavior, feeding behavior and development. Our results show that these mixtures could: a) reduce maternal behavior, b) change taste preferences (sweet, salty), c) affect the development from the in ut…

Perturbateurs endocriniens : effet sur les préférences gustatives et l'obésité

International audience; Plusieurs études relient l’évolution de l’incidence de l’obésité à une évolution sociétale: l’accès des femmes au travail, les facilités de transport et l’essor de l’industrie agroalimentaire ont généré une "transition nutritionnelle" où le repas mijoté à base de produits frais a fait place au repas vite-prêt et fast-foods. La surconsommation de graisses et sucres et la moindre consommation de fruits et légumes sont bien souvent incriminés. Toutefois, l’usage concomitant de produits chimiques dans la production agricole et la confection de produits raffinés et/ou transformés, pourrait être un facteur aggravant, le taux d’obésité pouvant atteindre 50% en régions pollu…

Early endocrine disruptors exposure acts on 3T3-L1 differentiation and endocrine activity

International audience; Introduction: Data from last years suggested that early exposure to endocrine disruptors (EDs) can predispose newborns to endocrine dysfunction of adipocytes, obesity, and associated disorders. The implication of EDs at low doses on adipocyte development has been poorly investigated. For instance, vinclozolin (V) is a dicarboximide fungicide widely used in agriculture since the 90's, alone or in mixture with genistein (G), an isoflavonoid from Leguminosae. This study aims to identify the effect of vinclozolin alone or with genistein, on adipose tissue properties using cell culture.Methods: In steroid-free conditions, 3T3-L1 pre-adipocytes were induced to differentiat…

Are taste preferences related to submandibular endocrine or exocrine secretions? A rodent study

National audience

L’exposition par des mélanges de perturbateurs endocriniens à faibles doses modifie la différenciation adipocytaire – CIME project

L’exposition par des mélanges de perturbateurs endocriniens à faibles doses modifie la différenciation adipocytaire – CIME project. Colloque PNR-PE