0000000001175313

AUTHOR

Nicole M. Smith

0000-0002-5519-8152

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DOTASQ as a prototype of nature-inspired G-quadruplex ligand

2011

DOTASQ (for DOTA-templated Synthetic G-quartet) is the first prototype of nature-inspired G-quadruplex ligand: its design, founded on a possible intramolecular G-quartet formation, enables it to interact with G-quadruplex DNA via an unprecedented nature-mimicking binding mode, based on the association between two G-quartets, one being native (quadruplex) and the other one artificial (ligand).

Models MolecularGuanineMacrocyclic CompoundsStereochemistryAntineoplastic AgentsLigands010402 general chemistryG-quadruplex01 natural sciencesCatalysischemistry.chemical_compoundMaterials ChemistryHumans[CHIM]Chemical SciencesNature inspiredTerbiumComputingMilieux_MISCELLANEOUSBinding SitesFourier Analysis010405 organic chemistryMetals and AlloysGeneral ChemistryLigand (biochemistry)0104 chemical sciencesSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsG-QuadruplexeschemistryMolecular ProbesIntramolecular forceCeramics and CompositesNucleic Acid ConformationHydrophobic and Hydrophilic InteractionsDNA
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