0000000001177601

AUTHOR

C. D'amato

showing 2 related works from this author

The dual PI3K/mTOR inhibitor PKI-587 enhances sensitivity to cetuximab in EGFR-resistant human head and neck cancer models

2014

Background:Cetuximab is the only targeted agent approved for the treatment of head and neck squamous cell carcinomas (HNSCC), but low response rates and disease progression are frequently reported. As the phosphoinositide 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR) pathways have an important role in the pathogenesis of HNSCC, we investigated their involvement in cetuximab resistance.Methods:Different human squamous cancer cell lines sensitive or resistant to cetuximab were tested for the dual PI3K/mTOR inhibitor PF-05212384 (PKI-587), alone and in combination, both in vitro and in vivo.Results:Treatment with PKI-587 enhances sensitivity to cetuximab in vitro, even in the co…

Cancer ResearchPathologyCetuximabApoptosisHNSCCHNSCCMiceAntineoplastic Combined Chemotherapy ProtocolsNeoplasmPhosphoinositide-3 Kinase InhibitorsMice Inbred BALB CCetuximabCaspase 3TriazinesTOR Serine-Threonine KinasesCetuximab resistanceErbB ReceptorsOncologyHead and Neck NeoplasmsMonoclonalCarcinoma Squamous Cellmedicine.drugmedicine.medical_specialtyMorpholinesPI3K-mTOR inhibitorsMice NudeAntineoplastic AgentsBiologyAntibodies Monoclonal HumanizedCell Line TumorAutophagymedicineCarcinomaAnimalsHumansneoplasmsPI3K/AKT/mTOR pathwayCell Proliferationcetuximab resistanceSquamous Cell Carcinoma of Head and Necktarget therapyCell growthAutophagyCancermedicine.diseaseXenograft Model Antitumor Assaysdigestive system diseasesDrug Resistance NeoplasmPI3K7mTOR inhibitorsCancer researchTranslational TherapeuticsBritish Journal of Cancer
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ANTARES: The first undersea neutrino telescope

2011

The ANTARES Neutrino Telescope was completed in May 2008 and is the first operational Neutrino Telescope in the Mediterranean Sea. The main purpose of the detector is to perform neutrino astronomy and the apparatus also offers facilities for marine and Earth sciences. This paper describes the design, the construction and the installation of the telescope in the deep sea, offshore from Toulon in France. An illustration of the detector performance is given. © 2011 Elsevier B.V. All rights reserved.

Optical telescopesPhysics::Instrumentation and DetectorsAstronomyMarine engineeringSubmarine cablesAstrophysics01 natural scienceslaw.inventionAstroparticlelaw010303 astronomy & astrophysicsInstrumentationPhysicsDense wavelength division multiplexingDetectorAstrophysics::Instrumentation and Methods for AstrophysicsDetectorsSubmarine cableDeep seaNeutrino astronomyFísica nuclearNeutrinoMarine technologyAstrophysics - Instrumentation and Methods for AstrophysicsNuclear and High Energy Physics[PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM]Wet mateable connectorAstrophysics::High Energy Astrophysical PhenomenaFOS: Physical sciencesLINEOptical telescopePhysics::GeophysicsTelescopePhotomultiplier tube0103 physical sciencesNeutrinoDWDM14. Life underwaterDeep sea detectorInstrumentation and Methods for Astrophysics (astro-ph.IM)DETECTORAstroparticle physics010308 nuclear & particles physicswet mateable connector.Marine technologyAstronomyElementary particles[SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM]PhotomultipliersKM3NeTFISICA APLICADAEarth (planet)High Energy Physics::ExperimentNeutrino astronomyastroparticle; neutrino astronomy; marine technology; dwdm; photomultiplier tube; deep sea detector; submarine cable; wet mateable connector; neutrinoSYSTEMTelescopes
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