0000000001178463
AUTHOR
C. Fabiani
Moderate influenza vaccine effectiveness against A(H1N1)pdm09 virus, and low effectiveness against A(H3N2) subtype, 2018/19 season in Italy
Background: Influenza vaccines are updated every year to match the vaccine strains with currently circulating viruses; consequently influenza vaccine effectiveness (IVE) has to be assessed annually.Research design and methods: A test-negative case-control study was conducted within the context of the Italian sentinel influenza surveillance network to estimate IVE by age group, virus subtype, and vaccine brand in medically attended laboratory-confirmed influenza.Results: In Italy, the 2018/19 influenza season was characterized by the co-circulation of influenza A(H1N1)pdm09 and A(H3N2) viruses. The adjusted IVE estimate in preventing influenza was moderate (44.8%, 95% CI: 18.8 to 62.5) again…
TASSO DI PERSISTENZA IN TERAPIA E FATTORI PREDITTIVI DI SOPRAVVIVENZA DEGLI INIBITORI DELL’INTERLEUCHINA 1 NELL’ARTRITE IDIOPATICA GIOVANILE A ESORDIO SISTEMICO
INTRODUZIONE L’introduzione dei farmaci biologici ha rivoluzionato l’approccio terapeutico nell’Artrite Idiopatica Giovanile a esordio Sistemico (SoJIA), modificando la storia naturale di questa malattia e migliorandone l’outcome globale. METODI Obiettivo principale dello studio era analizzare il tasso di persistenza in terapia (DRR) degli inibitori dell’Interleuchina (IL)-1 nei pazienti affetti da SoJIA. Obiettivi secondari dello studio erano: (1) esplorare l’influenza della linea biologica di trattamento, degli eventi avversi, dello specifico agente anti-IL-1 e del cotrattamento con disease modifying anti-rheumatic drugs (cDMARDs) sul DRR; (2) identificare eventuali fattori predittivi ass…
Co-circulation of SARS-CoV-2 Alpha and Gamma variants in Italy, February and March 2021
Background Several SARS-CoV-2 variants of concern (VOC) have emerged through 2020 and 2021. There is need for tools to estimate the relative transmissibility of emerging variants of SARS-CoV-2 with respect to circulating strains. Aim We aimed to assess the prevalence of co-circulating VOC in Italy and estimate their relative transmissibility. Methods We conducted two genomic surveillance surveys on 18 February and 18 March 2021 across the whole Italian territory covering 3,243 clinical samples and developed a mathematical model that describes the dynamics of co-circulating strains. Results The Alpha variant was already dominant on 18 February in a majority of regions/autonomous provinces (…