Author: Karolina Rosenfeld

0000000001182382

AUTHOR

Karolina Rosenfeld

showing 1 related works from this author

Laquinimod dampens IL-1β signaling and Th17-polarizing capacity of monocytes in patients with MS

2020

ObjectiveTo assess the impact of laquinimod treatment on monocytes and to investigate the underlying immunomodulatory mechanisms in MS.MethodsIn this cross-sectional study, we performed in vivo and in vitro analyses of cluster of differentiation (CD14+) monocytes isolated from healthy donors (n = 15), untreated (n = 13), and laquinimod-treated patients with MS (n = 14). Their frequency and the expression of surface activation markers were assessed by flow cytometry and the viability by calcein staining. Cytokine concentrations in the supernatants of lipopolysaccharide (LPS)-stimulated monocytes were determined by flow cytometry. The messenger ribonucleic acid (mRNA) expression level of gene…

AdultMale41Lipopolysaccharide[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/NeurobiologyCD14medicine.medical_treatmentInterleukin-1betaQuinolonesLymphocyte ActivationMonocytesArticleFlow cytometrychemistry.chemical_compoundMultiple Sclerosis Relapsing-RemittingDownregulation and upregulationmedicineHumansCD86medicine.diagnostic_testbusiness.industry[SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/NeurobiologyInterleukin[SDV.IMM.IMM]Life Sciences [q-bio]/Immunology/ImmunotherapyMiddle AgedMolecular biologyCross-Sectional StudiesCytokineNeurologychemistryTh17 CellsFemaleNeurology (clinical)[SDV.IMM.IMM] Life Sciences [q-bio]/Immunology/ImmunotherapybusinessLaquinimodSignal TransductionNeurology - Neuroimmunology Neuroinflammation

researchProduct

PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
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LSLife Sciences
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SHSocial Sciences and Humanities
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