0000000001182738
AUTHOR
Jin Huang
showing 2 related works from this author
Discovery of Natural Products as Novel and Potent FXR Antagonists by Virtual Screening
2018
Farnesoid X receptor (FXR) is a member of nuclear receptor family involved in multiple physiological processes through regulating specific target genes. The critical role of FXR as a transcriptional regulator makes it a promising target for diverse diseases, especially those related to metabolic disorders such as diabetes and cholestasis. However, the underlying activation mechanism of FXR is still a blur owing to the absence of proper FXR modulators. To identify potential FXR modulators, an in-house natural product database (NPD) containing over 4,000 compounds was screened by structure-based virtual screening strategy and subsequent hit-based similarity searching method. After the yeast t…
An Adaptive Metamodel-Based Optimization Approach for Vehicle Suspension System Design
2014
Published version of an article in the journal: Mathematical Problems in Engineering. Also available from the publisher at: http://dx.doi.org/10.1155/2014/965157 The performance index of a suspension system is a function of the maximum and minimum values over the parameter interval. Thus metamodel-based techniques can be used for designing suspension system hardpoints locations. In this study, an adaptive metamodel-based optimization approach is used to find the proper locations of the hardpoints, with the objectives considering the kinematic performance of the suspension. The adaptive optimization method helps to find the optimum locations of the hardpoints efficiently as it may be unachie…