Plasma leptin and vascular endothelial growth factor (VEGF) in normal subjects at high altitude (5050 m)

2013

Context: High altitude (HA) is a model of severe hypoxia exposure in humans. We hypothesized that nocturnal hypoxemia or acute maximal exercise at HA might affect plasma leptin and VEGF levels. Objectives: Plasma leptin, VEGF and other metabolic variables were studied after nocturnal pulse oximetry and after maximal exercise in healthy lowlanders on the 3rd-4th day of stay in Lobuche (5050 m, HA) and after return to sea level (SL). Results: Leptin was similar at SL or HA in both pre- and post-exercise conditions. Pre-exercise VEGF at HA was lower, and cortisol was higher, than at SL, suggesting that nocturnal intermittent hypoxia associated with periodic breathing at HA might affect these v…

Endurance training damages small airway epithelium in mice.

2007

RATIONALE: In athletes, airway inflammatory cells were found to be increased in induced sputum or bronchial biopsies. Most data were obtained after exposure to cold and dry air at rest or during exercise. Whether training affects epithelial and inflammatory cells in small airways is unknown. OBJECTIVES: To test whether endurance training under standard environmental conditions causes epithelial damage and inflammation in the small airways of mice. METHODS AND MEASUREMENTS: Formalin-fixed, paraffin-embedded lung sections were obtained in sedentary (n = 14) and endurance-trained (n = 16) Swiss mice at baseline and after 15, 30, and 45 days of training. The following variables were assessed (m…

Recovery of Damaged Skeletal Muscle in mdx Mice through Low-intensity Endurance Exercise

2013

The lack of dystrophin in mdx mice leads to cycles of muscle degeneration and regeneration processes. Various strategies have been proposed in order to reduce the muscle-wasting component of muscular dystrophy, including implementation of an exercise programme. The aim of this study was to examine how low-intensity endurance exercise affects the degeneration-regeneration process in dystrophic muscle of male mdx mice. Mice were subjected to low-intensity endurance exercise by running on a motorized Rota-Rod for 5 days/week for 6 weeks. Histomorphological analysis showed a signifi cant reduction of measured inflammatory-necrotic areas in both gastrocnemius and quadriceps muscle of exercised m…

Endurance raining damages small airway epithelium in mice

2005

Recovery of damaged skeletal muscle in mdx mice by low-intensity endurance exercise

2010

Plasma leptin and VEGF levels after maximal exercise at high altitude (5050 m)

2010

Involvement of nitric oxide in the nigrostriatal dopaminergic system degeneration: a study on the 6-OHDA model of Parkinson's disease.

2007

Bronchial epithelial thickness is increased in small airways of MDX mise at rest and after training

2009

Increased bronchial epithelial thickness in small airways of mdx mice at rest and after exercise training

2009

Increased numbers of inflammatory cells but decreased activation of NFkappaB pathway in small airways of endurance-trained mice.

2006

Effects of specific training on hormone levels in female athletes.

2008

Endurance training damages small airway epithelium in mice.

2005

Increased numbers of inflammatory cells but decreased activation of NFκB pathway in small airways of endurance-trained mice

2006

THE SUBSTANTIA NIGRA DOPAMINERGIC NEURONS

2007

Remodeling and inflammation of small airways in endurance trained mice

2006

Metabolic effects of hypoxia and sleep at high altitude(5050)

2010

Adaptations to long-term apnoea training

2010

ANTIOXIDANTS DIETERY INTAKE AND PARKINSON'S DISEASE

2007

Effects of endurance training on small airways of mice

2006