0000000001186920

AUTHOR

H. Kreppel

showing 2 related works from this author

Effect of antioxidants on sulfur mustard-induced toxicity in an in vitro-model of the human blood–air barrier

2007

chemistry.chemical_compoundHuman bloodChemistryToxicitySulfur mustardPharmacologyToxicologyIn vitro modelToxicology
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Assessment of alterations in barrier functionality and induction of proinflammatory and cytotoxic effects after sulfur mustard exposure of an in vitr…

2007

Acute lung injury after sulfur mustard (SM) inhalation is characterized by massive, localized hemorrhage and alveolar edema, which implies severe disruption of the vascular and distal airway barrier. In this study, we tested a recently established in vitro coculture model of the alveolo-capillary barrier for its applicability to investigate acute toxic effects of SM at the human respiratory unit. The epithelial compartment of cocultures was exposed to varying concentrations of SM (0-1000 microM; t = 30 min). Following exposure, functional and structural barrier integrity of cocultures was monitored over a period of 24 h. A 50% reduction of transbilayer electrical resistance (TER) within 12-…

Cell SurvivalHealth Toxicology and MutagenesisDNA FragmentationBiologyLung injuryToxicologyProinflammatory cytokinechemistry.chemical_compoundIn vivoCell Line TumorMustard GasHumansTUNEL assayBlood-Air BarrierInterleukinSulfur mustardMolecular biologyCoculture TechniquesCapillariesPulmonary AlveolichemistryCell cultureImmunologyLiberationChemokinesInflammation MediatorsInhalation toxicology
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