0000000001187952

AUTHOR

Olena Gruzieva

showing 3 related works from this author

Urban upbringing and childhood respiratory and allergic conditions: A multi-country holistic study

2018

Objective: We integratively assessed the effect of different indoor and outdoor environmental exposures early in life on respiratory and allergic health conditions among children from (sub-) urban areas. Methods: This study included children participating in four ongoing European birth cohorts located in three different geographical regions: INMA (Spain), LISAplus (Germany), GINIplus (Germany) and BAMSE (Sweden). Wheezing, bronchitis, asthma and allergic rhinitis throughout childhood were assessed using parental-completed questionnaires. We designed “environmental scores” corresponding to different indoor, green- and grey-related exposures (main analysis, a-priori-approach). Cohort-specific…

0301 basic medicine05 Environmental SciencesIndoor exposureFirst year of lifeMicrobial loadToxicologyBiochemistryGrey spaceAllergic rhinitis03 medical and health sciences0302 clinical medicineGermanyEnvironmental healthmedicineHumansRespiratory systemChildRespiratory SoundsGeneral Environmental ScienceAsthmaSwedenGreen space2. Zero hungerbusiness.industryEnvironmental ExposureOdds ratio06 Biological Sciencesmedicine.diseaseRhinitis AllergicAsthmaConfidence intervalConfirmatory factor analysis3. Good health030104 developmental biology030228 respiratory systemSpainBronchitisEnvironmental Pollutants03 Chemical SciencesbusinessAllergic Rhinitis ; Asthma ; Green Space ; Grey Space ; Indoor Exposure ; Microbial LoadMulti countryEnvironmental Research
researchProduct

DNA methylation in childhood asthma

2018

Background: DNA methylation profiles associated with childhood asthma might provide novel insights into disease pathogenesis. We did an epigenome-wide association study to assess methylation profiles associated with childhood asthma. Methods: We did a large-scale epigenome-wide association study (EWAS) within the Mechanisms of the Development of ALLergy (MeDALL) project. We examined epigenome-wide methylation using Illumina Infinium Human Methylation450 BeadChips (450K) in whole blood in 207 children with asthma and 610 controls at age 4–5 years, and 185 children with asthma and 546 controls at age 8 years using a cross-sectional case-control design. After identification of differentially m…

Male0301 basic medicineAllergyCytotoxicT-Lymphocytes[SDV]Life Sciences [q-bio]Respiratory Systemlnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]CHILDRENImmunoglobulin EEpigenesis GeneticChildPOPULATIONeducation.field_of_studybiologyMethylation3. Good healthCpG siteChild PreschoolDNA methylationFemaleBIOS ConsortiumLife Sciences & BiomedicinePulmonary and Respiratory MedicinePopulationPHENOTYPESIMMUNITY03 medical and health sciencesCritical Care MedicineGeneticGeneral & Internal MedicinemedicineHumansCOHORTEpigeneticsIGEEXPOSUREPreschooleducationAsthmaScience & Technologybusiness.industryRHINITISDNADNA Methylationmedicine.diseaseAsthmaEosinophils030104 developmental biology3121 General medicine internal medicine and other clinical medicineImmunologybiology.proteinGENOMEWIDE ASSOCIATIONCpG IslandsbusinessCOLLECTIONT-Lymphocytes CytotoxicEpigenesisGenome-Wide Association StudyThe Lancet. Respiratory Medicine
researchProduct

Shared DNA methylation signatures in childhood allergy: The MeDALL study

2021

Contains fulltext : 232514.pdf (Publisher’s version ) (Open Access) BACKGROUND: Differential DNA methylation associated with allergy might provide novel insights into the shared or unique etiology of asthma, rhinitis, and eczema. OBJECTIVE: We sought to identify DNA methylation profiles associated with childhood allergy. METHODS: Within the European Mechanisms of the Development of Allergy (MeDALL) consortium, we performed an epigenome-wide association study of whole blood DNA methylation by using a cross-sectional design. Allergy was defined as having symptoms from at least 1 allergic disease (asthma, rhinitis, or eczema) and positive serum-specific IgE to common aeroallergens. The discove…

0301 basic medicineMaleAllergyMESH: Asthmalnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]EczemaImmunoglobulin EEpigenesis GeneticCohort Studies0302 clinical medicineMESH: DNA MethylationMESH: ChildImmunology and AllergyMedicineMESH: Epigenesis GeneticChildMESH: CpG IslandsMESH: Cohort StudiesDNA methylationbiologyMESH: Immunoglobulin EEpigeneticMethylation3. Good healthCpG site030220 oncology & carcinogenesisChild PreschoolDNA methylationMESH: Rhinitis AllergicFemaleEpigeneticsIgEAdolescentMESH: HypersensitivityImmunologyeducationSingle-nucleotide polymorphismArticle03 medical and health sciencesMESH: Cross-Sectional StudieschildrenHypersensitivityHumansEpigeneticsAsthmaMESH: AdolescentMESH: Humansbusiness.industryMESH: TranscriptomeMESH: Child PreschoolImmunoglobulin Emedicine.diseaseallergyRhinitis AllergicAsthmaMESH: Male030104 developmental biologyCross-Sectional StudiesMESH: Eczema3121 General medicine internal medicine and other clinical medicineImmunologybiology.proteinCpG IslandsbusinessTranscriptomeMESH: Female[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
researchProduct