Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients

Item does not contain fulltext BACKGROUND: Bococizumab is a humanized monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and reduces levels of low-density lipoprotein (LDL) cholesterol. We sought to evaluate the efficacy of bococizumab in patients at high cardiovascular risk. METHODS: In two parallel, multinational trials with different entry criteria for LDL cholesterol levels, we randomly assigned the 27,438 patients in the combined trials to receive bococizumab (at a dose of 150 mg) subcutaneously every 2 weeks or placebo. The primary end point was nonfatal myocardial infarction, nonfatal stroke, hospitalization for unstable angina requiring urgent re…

Role of Electrical Charges on the Adsorption of Hydrogen: Something Old, Something New

When less is more: more cations means more adsorption sites for toluene in zeolites?

The unique properties of zeolites makes them an interesting material to be used in separation processes. The possibility of tailoring some of their characteristics, like the Si/Al ratio, allows to optimize their synthesis for a given task. Concerning the adsorption of toluene by faujasites, an understanding of the effect of cations is necessary to foster the elaboration of new materials, which can capture molecules from humid environments with a high selectivity and sensibility. Undoubtedly, this knowledge is relevant for a wide range of applications going from the elaboration of technologies for improving the air-quality to the elaboration of diagnostic procedures to prevent health risks. …

Large-scale gene discovery in the pea aphid Acyrthosiphon pisum (Hemiptera)

A large-scale sequencing analysis of the Hemiptera Acyrthosiphon pisumexpressed sequence tags corresponding to about 12,000 unique transcripts is described, along with an in silico profiling analysis that identifies 135 aphid tissue-specific transcripts.