0000000001192282
AUTHOR
P Richiusa
showing 30 related works from this author
Functional and molecular charecterizzation of cancer stam cells in anaplastic thyroid carcinoma
2011
Th1 and Th2 cell phenotypes in AITD: role of allergy in Graves' disease
2004
L’espressione di citochine TH1 e TH2 nei pazienti affetti da tireopatia autoimmune (AITD) e diabete di tipo 1
2004
Search for the mutation of B-RAFV600E in FNA of thyroid nodules
2006
L’uso del hrTSH nel follow up del microcarcinoma tiroideo in pazienti sottoposti a tiroidectomia totale
2004
BIOINFORMATICS CERNA ANALYSIS FOR THE STUDY OF STEM FACTOR SOX2 IN ANAPLASTIC THYROID CANCER.
2013
Cancer stem cells (CSC) are believed to play a central role in oncogenesis, but until today their isolation and characterization is still particularly complex. Anaplastic thyroid cancer (ATC) presents several characteristics suggestive of a tumour highly enriched in CSC (high mitotic rate, poor prognosis, high aggressiveness, resistance to treatments, etc). For these reasons ATC represents a good candidate to study CSCs. SOX2 is a key stem transcriptional factor, usually only transiently expressed, that plays a fundamental role in stem cell identity. SOX2 proved to be constitutively expressed in SW1736 cell line, a well established and recognized ATC cell line. The bioinformatics ceRNA anal…
BRAFV600E mutation and timp-1 hyper-expression in classical variants of papillary thyroid carcinoma (PTC).
2009
Identification and enrichment of thyroid stem cells in anaplastic cell lines
2008
Multiple Pluripotent Stem Cell Markers in Human Anaplastic Thyroid Cancer: The Putative Upstream Role of SOX2
2013
Anaplastic thyroid carcinoma (ATC) is a rare and aggressive endocrine tumor with highly undifferentiated morphology. It has been suggested that cancer stem cells (CSCs) might play a central role in ATC. The objectives of this study were (i) to characterize CSCs from ex vivo ATC specimens by investigating the expression of several pluripotent stem cell markers, and (ii) to evaluate in vitro drug resistance modifications after specific CSC transcription factor switch-off.In ex vivo experiments, eight formalin-fixed, paraffin-embedded ATC specimens were analyzed by reverse-transcription and real-time quantitative PCR and immunohistochemistry. In in vitro experiments using ATC SW1736 cells, the…
Limbal stem cells as a potential source of pancreatic beta cells
2009
BACKGROUND/RATIONAL Beta cell replacement therapy represents an alternative approach to conventional insulin regimen for the management of type 1 diabetes. Stem cells theoretically represent a suitable and renewable source of surrogate beta cells. Recently, it has been demonstrated that corneal epithelium contains stem cells in the basal layer of the limbus. Our aim was to isolate and characterize limbal stem cells (LSCs) from adult corneal-limbal biopsies, and to assess their capability to differentiate into insulin-producing cells. METHODS 2-3 mm2 biopsies were obtained from limbus and central cornea of four patients undergoing surgery for ocular diseases not involving conjuctive or corne…
No association between BRAFV660E and metalloproteinase activity in anaplastic thyroid cell lines
2008
No effect of GH/IGF-1 excess on adrenal gland in Acromegalic patients.
2007
Molecular characterization of cancer stem cells in anaplastic thyroid carcinoma
2009
Identification and enrichment of thyroid cancer stem cells in anaplastic cell lines
2008
Iter diagnostico "rapido" per un caso di MEN IIb in un giovane adolescente
2004
Cellule Staminali Pancreatiche
2004
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Fine-Needle Aspiration (FNAB) Molecular Analysis for the Diagnosis of Papillary Thyroid Carcinoma through BRAFv600E mutation and RET/PTC rearrangement
2007
Objective: To evaluate BRAFV600E mutation on consecutive fine-needle aspiration biopsy (FNAB) specimens in order to assess FNAB’s usefulness in preoperative papillary thyroid carcinoma (PTC) diagnosis with the contemporaneous analysis of RET=PTC1 and RET=PTC3 rearrangements obtained from ex vivo thyroid nodules. Design: Thyroid FNABs from 156 subjects with nodules and 49 corresponding surgical samples were examined for the presence of BRAF mutation by real-time allele-specific polymerase chain reaction, confirmed with the use of a laser pressure catapulting system. Samples were also examined for RET=PTC rearrangements. The results were compared with the cytological diagnosis and histopathol…
Azione antalgica di Hydrogel nell'orbitopatia basedowiana
2007
La terapia dell'orbitopatia,nella fase acuta,si basa oltre che sulla correzione della turba endocrinologica,sulla protezione della cornea e sull'uso dei corticosteroidi ad alto dosaggio o di farmaci immunosoppressori o, in alternativa,sulla radioterapia orbitaria.Per attenuare la sintomatologia dolorosa,frequente nella fase acuta e che può inficiare la qualità della vita,data la componente flogistica,abbiamo voluto valutare gli effetti di una terapia antalgica mediante appliocazione sulla superficie palpebrale di un gel chirurgico criogenico decongestinante ( a contenuto di estratto di ananas più acido betaglicirretico),ad oggi utilizzato con risultati soddisfacenti in soggetti sottoposti a…
Effetti di una terapia con glucocorticoidi ev ad alte dosi sull'oftalmopatia di Graves moderata-severa:uno studio caso-controllo
2014
BRAFV660E mutation and Timp-1 hyper-expression in classical variants of papyllary thyroid carcinoma.
2009
Different Th1/Th2 cytokine expression in Type 1 diabetes mellitus patients (T1DM) alone or associated with autoimmune thyroid disease (AITD)
2004
Decreased regulatory CD4+CD25+ Treg cells in newly diagnosed type 1 diabetes
2003
BrafV600E mutation and hyperexpression of tissue inhibitor of metalloproteinases-1 (TIMP-1) in papillary thyroid carcinoma
2009
Predittori comportamentali, metabolici ed antropometrici di piede diabetico in una popolazione di diabetici di tipo 2.
2014
The use of rh-TSH in the follow-up of thyroid microcarcinoma after total thyroidectomy
2005
Trattamento con lanreotide di un caso di gastrinoma già trattao con 177Lu-DOTATATE
2009
Differente pattern di espressione di citochine a fenotipo Th1 e Th2 nei pazienti affetti da diabete di tipo 1 (T1DM) e con associata tireopatia autoi…
2004
L’espressione del “peroxisome proliferator-activated gamma” (PPARgamma) nelle tireopatie croniche autoimmuni
2003
The sonographic pattern of neck lymph nodes in chronic autoimmune thyroiditis.
2013
Background: Neck lymph nodes may be involved in the pathogenesis of chronic autoimmune thyroiditis (CAT).We hypothesized that the involvement of cervical lymph nodes in CAT may be associated with a different sonographic pattern of neck nodes in comparison to subjects without CAT. Methods: We included 106 patients (92 females and 14 males) with CAT and 70 control subjects (53 females andm17 males) without clinical, biochemical, and ultrasonographic evidence of thyroid and neck diseases. We performed laboratory tests (thyrotropin, antithyroperoxidase antibodies, antithyroglobulin antibodies, and ultrasonography) to evaluate in each group: (i) thyroid function, autoimmunity, and morphology; (i…