0000000001192464
AUTHOR
L Toniolo
MOLECULAR SIGNALLING RESPONSE TO SHORT DURATION HIGH INTENSITY/LOW VOLUME RESISTANCE TRAINING IN HUMAN SKELETAL MUSCLE.
Introduction Resistance training (RT) is one of the most important stimuli for muscle hypertrophy, but it may play also an important role on weight loss and fat acid (FA) oxidation increase. It has been largely demonstrated that RT affects anabolic signalling molecule phosphorylation but, considering the numerous variables of RT, the differences between training modalities has been till now poorly investigated. The aim of this study was to assess Akt, 4EBP1, S6 and AMPK, ACC signalling after a single bout of high-intensity resistance training (HIRT) and of traditional resistance training (TRT). Methods 12 healthy subjects performed in two different moments and with different legs HIRT and T…
PARADOXICAL EFFECT OF RESISTANCE TRAINING AND HIGH PROTEIN DIET ON PLASMA MYOSTATIN RESPONSE TO EXERCISE
Introduction In recent years, a mounting amount of evidence have suggested that contracting muscle can act as a cytokine producing organ that may influence metabolism (Pedersen 2010). Myostatin (MSTN) relationship with body fat amount, training status and nutrition has been widely investigated but with conflicting results. Although MSTN inhibits the Akt/mTor pathway some studies have shown also an counterintuitive positive correlation between MSTN and muscle mass (myostatin paradox). Moreover MSTN has been shown to reduce IGF-1 stimulated AKT phosphorylation in a dose-dependent manner. We investigated the influence of two months of resistance training (RT) and high protein diet on plasma my…