PARADOXICAL EFFECT OF RESISTANCE TRAINING AND HIGH PROTEIN DIET ON PLASMA MYOSTATIN RESPONSE TO EXERCISE

Introduction In recent years, a mounting amount of evidence have suggested that contracting muscle can act as a cytokine producing organ that may influence metabolism (Pedersen 2010). Myostatin (MSTN) relationship with body fat amount, training status and nutrition has been widely investigated but with conflicting results. Although MSTN inhibits the Akt/mTor pathway some studies have shown also an counterintuitive positive correlation between MSTN and muscle mass (myostatin paradox). Moreover MSTN has been shown to reduce IGF-1 stimulated AKT phosphorylation in a dose-dependent manner. We investigated the influence of two months of resistance training (RT) and high protein diet on plasma my…