0000000001196945

AUTHOR

Annie Beuve

showing 1 related works from this author

Hypothalamic S-Nitrosylation Contributes to the Counter-Regulatory Response Impairment following Recurrent Hypoglycemia

2013

http://www.ncbi.nlm.nih.gov/pubmed/23894333; International audience; AIMS: Hypoglycemia is a severe side effect of intensive insulin therapy. Recurrent hypoglycemia (RH) impairs the counter-regulatory response (CRR) which restores euglycemia. During hypoglycemia, ventromedial hypothalamus (VMH) production of nitric oxide (NO) and activation of its receptor soluble guanylyl cyclase (sGC) are critical for the CRR. Hypoglycemia also increases brain reactive oxygen species (ROS) production. NO production in the presence of ROS causes protein S-nitrosylation. S-nitrosylation of sGC impairs its function and induces desensitization to NO. We hypothesized that during hypoglycemia, the interaction b…

Central Nervous SystemMaleespèce active de l'oxygènemedicine.medical_treatmentlcsh:Medicinechemistry.chemical_compoundEndocrinology0302 clinical medicineDesensitization (telecommunications)Insulinhypothalamuslcsh:ScienceNeurons0303 health sciencesMultidisciplinaryStatisticsNeurochemistryOrvostudományokAnimal Models[ SDV.MHEP.EM ] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism3. Good healthEpinephrineHomeostatic MechanismsAlimentation et NutritionMedicineNeurochemicalshypoglycémieResearch Articlediabètemedicine.drugmedicine.medical_specialtyRecurrent hypoglycemiamonoxide d'azoteinsulino-thérapie intensiveNeurophysiologyBiostatisticsHypoglycemiaKlinikai orvostudományokNitric OxideGlucagonNitric oxide03 medical and health sciencesModel OrganismsInternal medicinemedicineFood and NutritionAnimalscontre-régulationBiologyNutrition030304 developmental biologyDiabetic EndocrinologyEndocrine Physiologybusiness.industryInsulinlcsh:Rneurone sensible au glucosenutritional and metabolic diseasesmonoxide d'azote;espèce active de l'oxygène;S-nitrosylation;hypoglycémie;neurone sensible au glucose;hypothalamus;contre-régulation;diabète;insulino-thérapie intensiveDiabetes Mellitus Type 1NeuroendocrinologyDiabetes Mellitus Type 2medicine.diseaseHypoglycemiaS-nitrosylationAcetylcysteineRatsGlucoseEndocrinologychemistryMetabolic DisordersRatlcsh:QReactive Oxygen SpeciesbusinessSoluble guanylyl cyclaseMathematics030217 neurology & neurosurgeryNeurosciencePLoS ONE
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