0000000001203358

AUTHOR

Ved Prakash Verma

0000-0003-2142-2459

showing 2 related works from this author

Construction of Spirooxindole Analogues Engrafted with Indole and Pyrazole Scaffolds as Acetylcholinesterase Inhibitors

2021

Twenty-five new hits of spirooxindole analogs 8a–y engrafted with indole and pyrazole scaffolds were designed and constructed via a [3+2]cycloaddition (32CA) reaction starting from three components: new chalcone-based indole and pyrazole scaffolds 5a–d, substituted isatins 6a–c, and secondary amines 7a–d. The potency of the compounds were assessed in modulating cholinesterase (AChE) activity using Ellman’s method. Compounds 8i and 8y showed the strongest acetylcholine esterase inhibition (AChEI) with IC50 values of 24.1 and 27.8 μM, respectively. Molecular docking was used to study their interaction with the active site of hAChE. peerReviewed

Indole testChemistryStereochemistrybioaktiiviset yhdisteetGeneral Chemical EngineeringGeneral ChemistryPyrazoleindolespeptides and proteinsAcetylcholinesterasemolecular mechanicsArticleinhibitionchemistry.chemical_compoundChemistryscaffoldsQD1-999orgaaniset yhdisteetinhibiittorit
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CCDC 2105913: Experimental Crystal Structure Determination

2022

Related Article: Mohammad Shahidul Islam, Abdullah Mohammed Al-Majid, Mohammad Azam, Ved Prakash Verma, Assem Barakat, Matti Haukka, Abdullah A. Elgazar, Amira Mira, Farid A. Badria|2021|ACS Omega|6|31539|doi:10.1021/acsomega.1c03978

Space GroupCrystallographyCrystal SystemCrystal Structure7'-(5-bromo-1H-indol-3-yl)-6'-(5-methyl-1-phenyl-1H-pyrazole-4-carbonyl)-1'6'7'7'a-tetrahydro-3'H-spiro[indole-35'-pyrrolo[12-c][13]thiazol]-2(1H)-one chloroform solvateCell ParametersExperimental 3D Coordinates
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