Effects of hypertonic/hyperoncotic treatment and surgical evacuation after acute subdural hematoma in rats*

Objective: The treatment of acute subdural hematoma (ASDH) consists mainly of surgical evacuation of the hematoma. It is conceivable that early preoperative neuroprotection with hypertonic/hyperoncotic treatment (HHT) can improve survival rates. The present study investigated the benefit of treatment with hypertonic/hyperoncotic solution on functional and histologic outcome as supportive therapy accompanying surgical intervention. Design: Laboratory experiment. Setting: University laboratory. Subjects: Male Sprague-Dawley rats weighing 296–350 g (n = 56). Interventions: ASDH was induced through subdural infusion of 400 μL of autologous venous blood. Thirty minutes after subdural blood infus…