ApoE polymorphism in a small Mediterranean island: Relationships with plasma lipids, lipoproteins and LDL particle size

Polymorphisms of apoE gene are able to modulate lipoprotein metabolism at different steps and to influence LDL-cholesterol (LDL-C) levels and also other lipoproteins features. Population studies documented large differences in the frequency of apoE alleles which could be even related to the prevalence of cardiovascular disease. In this study we evaluated the apoE genotypes and allele frequency in 576 subjects living in a small island in the Tyrrhenian Sea and the relative contribution of apoE polymorphism on plasma lipid and lipoprotein profile, including LDL particle size. We found a cumulative frequency of 0.073, 0.866 and 0.061 for ε2, ε3 and ε4 alleles respectively. Moreover ε3 subjects…

Levels of b-sitosterol in a sicilian sample of hyper-cholesterolemic patients

Low prevalence of the atherogenic small, dense LDL in a mediterranean population. Nutrition, Metabolism and Cardiovascular Diseases

Bassa prevalenza delle LDL aterogene piccole e dense in una popolazione mediterranea

Livelli di b-sitosterolo in una popolazione siciliana di pazienti ipercolesterolemici