Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019

Background Accurate and up-to-date assessment of demographic metrics is crucial for understanding a wide range of social, economic, and public health issues that affect populations worldwide. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 produced updated and comprehensive demographic assessments of the key indicators of fertility, mortality, migration, and population for 204 countries and territories and selected subnational locations from 1950 to 2019. Methods 8078 country-years of vital registration and sample registration data, 938 surveys, 349 censuses, and 238 other sources were identified and used to estimate age-specific fertility. Spatiotemporal Gaussian…

FOLLOW-UP AFTER PEDIATRIC MYRINGOPLASTY: OUTCOME AT 5 YEARS

Aim. The aim of this paper was to evaluate anatomical and functional outcomes 5 years after myringoplasty in children affected by perforated eardrum. To analyze the main differences in the frequency of postoperative complications between patients under and over 9 years of age. Methods. One hundred and thirty-two children, aged from 4 to 15 years, who underwent myringoplasty with or without mastoidectomy, were followed for a five-year period after surgery. The cohort was divided in two groups: children from 4 to 9 years old (G1) and patients older than 9 years (G2); all subjects underwent a pre- and post-operatively clinical exam and were evaluated through audiometry and impedenzometry. Aden…

Anatomia e patologia del labirinto membranoso studio con sequenze RM sensibili al flusso

Nonostante i deludenti esordi nella valutazione delle strutture labirintiche costituenti l'orecchio interno, la risonanza magnetica costituisce oggi, grazie anche al miglioramento dell'hardware e del software disponibili, una modalità diagnostica di grande efficacia non solo nell'analisi della patologia espansiva o infiammatoria coinvolgente il VII ed VIII nervo cranico, ma anche nella valutazione delle alterazioni patologiche del segnale endolabirintico in rapporto a focolai emorragici o, come recentemente dimostrato mediante uso di Gd-DTPA, nell'analisi delle alterazioni a carico della capsula oticanella fase spongiotica dell'otosclerosi. Tuttavia, lo scarso contrasto esistente tra liqui…

Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burden of Disease Study 2019

Background: Sustainable Development Goal 3.2 has targeted elimination of preventable child mortality, reduction of neonatal death to less than 12 per 1000 livebirths, and reduction of death of children younger than 5 years to less than 25 per 1000 livebirths, for each country by 2030. To understand current rates, recent trends, and potential trajectories of child mortality for the next decade, we present the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 findings for all-cause mortality and cause-specific mortality in children younger than 5 years of age, with multiple scenarios for child mortality in 2030 that include the consideration of potential effects of COVID-…

LA POSTUROGRAFIA STATICA

SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study

Abstract Background Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18–49, 50–69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results NNVs were more favourable in su…

La timpanoplastica aperta: indicazioni e nostri risultati a distanza

OBIETTIVI Le indicazioni per una tecnica aperta sono in primo luogo le otomastoiditi colesteatomatose, le neoplasie, alcune complicanze ed alcune forme di otomastoidite granulomatosa diffusa con totale coinvolgimento della catena ossiculare, specialmente quando esiste una mastoide eburmnea. MATERIALI Nel periodo 1975‐2006 sono state eseguite 4875 timpanoplastiche, di cui 3343 con tecnica aperta. In considerazione dell'esperienza maturata è utile distinguere un periodo compreso tra il 1975 e 1990, nel quale, indipendentemente dalla diagnosi, si eseguiva la tecnica chiusa nel 95% dei casi, mentre la tecnica aperta era riservata al 5% dei casi. Nell'85% delle tecniche chiuse veniva eseguito un…

Experimental results of a low cost weather buoy

Five insights from the Global Burden of Disease Study 2019

The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a rules-based synthesis of the available evidence on levels and trends in health outcomes, a diverse set of risk factors, and health system responses. GBD 2019 covered 204 countries and territories, as well as first administrative level disaggregations for 22 countries, from 1990 to 2019. Because GBD is highly standardised and comprehensive, spanning both fatal and non-fatal outcomes, and uses a mutually exclusive and collectively exhaustive list of hierarchical disease and injury causes, the study provides a powerful basis for detailed and broad insights on global health trends and emerging challenges. GBD …

The overlapping burden of the three leading causes of disability and death in sub-Saharan African children

Publisher Copyright: © 2022, The Author(s). Despite substantial declines since 2000, lower respiratory infections (LRIs), diarrhoeal diseases, and malaria remain among the leading causes of nonfatal and fatal disease burden for children under 5 years of age (under 5), primarily in sub-Saharan Africa (SSA). The spatial burden of each of these diseases has been estimated subnationally across SSA, yet no prior analyses have examined the pattern of their combined burden. Here we synthesise subnational estimates of the burden of LRIs, diarrhoea, and malaria in children under-5 from 2000 to 2017 for 43 sub-Saharan countries. Some units faced a relatively equal burden from each of the three diseas…

RARO CASO DI IPERPLASIA ANGIOLINFOIDE CON EOSINOFILIA DELLA REGIONE MASTOIDEA

L’iperplasia angiolinfoide con eosinofilia (ALHE) è una rara malattia benigna ad eziologia poco chiara, anche se la malattia viene considerata dalla maggior parte degli autori un processo reattivo o di natura vascolare amartomatosa. Colpisce con leggera prevalenza il sesso femminile tra la III e la V decade ed è caratterizzata da lesioni papulose e nodulari con sede elettiva al capo, al collo e al condotto uditivo esterno, senza linfadenopatia e con lieve eosinofilia periferica. Dal punto di vista istologico è presente una proliferazione vascolare dermica e/o ipodermica accompagnata da un infiltrato in gran parte costituito da linfociti, istiociti ed eosinofili. Gli autori descrivono un cas…

Otite media atelettasica, adesiva, timpanosclerotica: update medico e chirurgico

Otitis media secretive is one of the most common ear diseases characterized by frequent sequelae and complications; in particular the authors describe middle ear atelectasis with pocket retraction of tympanic membrane, pocket retraction limited to pars tensa or to pars flaccida, adhesive otitis media, partial or total myringosclerosis and tympanosclerosis. For each disease the Authors comment the best surgical approaches to preserve and restore conductive hearing loss. As for middle ear atelectasis, adhesive otitis media, myringosclerosis and partial tympanosclerosis it was evidenced a significant hearing gain while in total tympanosclerosis there was an initial hearing improvement in a sho…