Author: Mohamed Saeed

0000000001226587

AUTHOR

Mohamed Saeed

showing 2 related works from this author

Oridonin Targets Multiple Drug-Resistant Tumor Cells as Determined by in Silico and in Vitro Analyses

2018

Drug resistance is one of the main reasons of chemotherapy failure. Therefore, overcoming drug resistance is an invaluable approach to identify novel anticancer drugs that have the potential to bypass or overcome resistance to established drugs and to substantially increase life span of cancer patients for effective chemotherapy. Oridonin is a cytotoxic diterpenoid isolated from Rabdosia rubescens with in vivo anticancer activity. In the present study, we evaluated the cytotoxicity of oridonin toward a panel of drug-resistant cancer cells overexpressing ABCB1, ABCG2, or ΔEGFR or with a knockout deletion of TP53. Interestingly, oridonin revealed lower degree of resistance than the control dr…

0301 basic medicineDrug resistancenatural compound03 medical and health sciences0302 clinical medicineIn vivomedicinePharmacology (medical)DoxorubicinProtein kinase BPI3K/AKT/mTOR pathwayOriginal ResearchPharmacologydrug resistanceChemistrylcsh:RM1-950molecular dockingmolecular dynamics030104 developmental biologylcsh:Therapeutics. PharmacologyDocking (molecular)030220 oncology & carcinogenesisPharmacogenomicsCancer cellCancer researchmicroarraymedicine.drugcluster analysisFrontiers in Pharmacology

researchProduct

CCDC 2081480: Experimental Crystal Structure Determination

2022

Related Article: Leander Geske, Ulrich Kauhl, Mohamed Saeed, Anja Schüffler, Eckhard Thines, Thomas Efferth, Till Opatz|2021|Molecules|26|3224|doi:10.3390/molecules26113224

Space GroupCrystallographyCrystal SystemCrystal Structure5-[2-(3-hydroxyphenyl)ethyl]-4-[(4-hydroxyphenyl)methyl]benzene-13-diolCell ParametersExperimental 3D Coordinates

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PEPhysical Sciences and Engineering
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LSLife Sciences
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