On the Antibacterial Activity of Azacarboxylate Ligands: Lowered Metal Ion Affinities for Bis-amide Derivatives of EDTA do not mean Reduced Activity.
EDTA is widely used as an inhibitor of bacterial growth, affecting the uptake and control of metal ions by microorganisms. We describe the synthesis and characterisation of two symmetrical bis-amide derivatives of EDTA, featuring glycyl or pyridyl substituents: AmGly2 and AmPy2 . Metal ion affinities (logK) have been evaluated for a range of metals (Mg2+ , Ca2+ , Fe3+ , Mn2+ , Zn2+ ), revealing less avid binding compared to EDTA. The solid-state structures of AmGly2 and of its Mg2+ complex have been determined crystallographically. The latter shows an unusual 7-coordinate, capped octahedral Mg2+ centre. The antibacterial activities of the two ligands and of EDTA have been evaluated against …
CCDC 1814350: Experimental Crystal Structure Determination
Related Article: Raminder S. Mulla, Marikka S. Beecroft, Robert Pal, Juan A. Aguilar, Javier Pitarch‐Jarque, Enrique García‐España, Elena Lurie‐Luke, Gary J. Sharples, J. A. Gareth Williams|2018|Chem.-Eur.J.|24|7137|doi:10.1002/chem.201800026
CCDC 1814351: Experimental Crystal Structure Determination
Related Article: Raminder S. Mulla, Marikka S. Beecroft, Robert Pal, Juan A. Aguilar, Javier Pitarch‐Jarque, Enrique García‐España, Elena Lurie‐Luke, Gary J. Sharples, J. A. Gareth Williams|2018|Chem.-Eur.J.|24|7137|doi:10.1002/chem.201800026
CCDC 1814349: Experimental Crystal Structure Determination
Related Article: Raminder S. Mulla, Marikka S. Beecroft, Robert Pal, Juan A. Aguilar, Javier Pitarch‐Jarque, Enrique García‐España, Elena Lurie‐Luke, Gary J. Sharples, J. A. Gareth Williams|2018|Chem.-Eur.J.|24|7137|doi:10.1002/chem.201800026