Study of the role of BCL-XL in healthy aging and frailty prevention

2022

Aging is defined as an intrinsic, progressive, deleterious and inevitable multifactorial phenomenon that occurs as a result of the gradual accumulation of damage at cellular and molecular levels. Due to the recent discovery of BCL-XL being overexpressed in peripheral blood mononuclear cells from centenarians, a new approach has emerged to investigate the BCL-XL function in healthy aging. The major goal of this thesis is to study the role of BCL-XL in frailty and healthy aging in transgenic mice overexpressing a human form of BCL-XL in T cells. For this, we used the heterozygous transgenic mice from Cg-Tg(LCKprBCL2L1)12Sjk/J strain, which express the human BCL-XL cDNA sequence in all thymocy…