Role of TP53 codon 72 polymorphism in Cardiovascular diseases: A STUDY ON ITALIAN POPULATION

Genes, Ageing and Longevity in Humans: Problems, Advantages and Perspectives.

Many epidemiological data indicate the presence of a strong familial component of longevity that is largely determined by genetics, and a number of possible associations between longevity and allelic variants of genes have been described. A breakthrough strategy to get insight into the genetics of longevity is the study of centenarians, the best example of successful ageing. We review the main results regarding nuclear genes as well as the mitochondrial genome, focusing on the investigations performed on Italian centenarians, compared to those from other countries. These studies produced interesting results on many putative "longevity genes". Nevertheless, many discrepancies are reported, l…

Polimorfismi genetici di p53, apoe e IL-6 e malattie cardiovascolari nell’anziano: lo studio"IN CHIANTI"

Prevalenza degli autoanticorpi in una coorte di soggetti anziani e centenari