0000000001237705

AUTHOR

Marzia Duse

showing 10 related works from this author

Clinical evaluation and treatment of acute asthma exacerbations in children

2009

This update on treatment of asthma exacerbations in children is the result of an Italian Pediatric Society Task-force, made up of a panel of experts working in 2007–2008. The aim is to give clear indications on the use of the drugs most employed in children, grading the quality of evidence and the strength of recommendations. Suggestions on their limits due to unlicensed and off-label use are reported. The level of evidence and the strength of recommendations for different therapeutic approaches demonstrate that frequently the use of drugs in children is extrapolated from the experience in adults and that more studies are required to endorse the correct use of different drugs in asthmatic …

medicine.medical_specialtyImmunologyMEDLINESeverity of Illness Index; Acute Disease; Evidence-Based Medicine; Off-Label Use; Hospitalization; Humans; Treatment Outcome; Practice Guidelines as Topic; Asthma; Anti-Asthmatic Agents; Child; Child PreschoolOff-label useSeverity of Illness IndexSeverity of illnessHumansAnti-Asthmatic AgentImmunology and AllergyMedicineAnti-Asthmatic AgentsChildIntensive care medicineGrading (education)PharmacologyEvidence-Based MedicineAsthma exacerbationsbusiness.industryOff-Label UseEvidence-based medicineAsthmaHospitalizationQuality of evidenceacute asthma; children; emergency treatmentTreatment OutcomeSettore MED/38 - PEDIATRIA GENERALE E SPECIALISTICAChild PreschoolAcute DiseasePractice Guidelines as Topicacute asthma exacerbations in childrenbusinessacute asthma exacerbations in children.Clinical evaluationHuman
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Inter-society consensus for the use of inhaled corticosteroids in infants, children and adolescents with airway diseases

2021

Abstract Background In 2019, a multidisciplinary panel of experts from eight Italian scientific paediatric societies developed a consensus document for the use of inhaled corticosteroids in the management and prevention of the most common paediatric airways disorders. The aim is to provide healthcare providers with a multidisciplinary document including indications useful in the clinical practice. The consensus document was intended to be addressed to paediatricians who work in the Paediatric Divisions, the Primary Care Services and the Emergency Departments, as well as to Residents or PhD students, paediatric nurses and specialists or consultants in paediatric pulmonology, allergy, infecti…

MaleDelphi TechniqueRhinosinusitisRespiratory Tract DiseasesDelphi methodRhinosinusitiLaryngitisAdrenal Cortex HormonePediatrics0302 clinical medicineAdrenal Cortex HormonesMultidisciplinary approachInhaled corticosteroid030212 general & internal medicineChildRespiratory Tract DiseaseRhinitiSocieties MedicalRhinitiseducation.field_of_studyInhaled corticosteroidsWheezing.General MedicineSettore MED/38Systematic reviewItalyLaryngotracheitisChild PreschoolLaryngotracheitiFemalemedicine.symptomHumanmedicine.medical_specialtyConsensusAdolescentPopulationConsensuRJ1-57003 medical and health sciencesIntervention (counseling)Administration InhalationmedicineLaryngospasmHumansAdenoid hypertrophyLaryngospasmeducationIntensive care medicineAsthmaWheezingbusiness.industryResearchInfantmedicine.diseaseAsthma030228 respiratory systemAdenoid hypertrophy; Asthma; Inhaled corticosteroids; Laryngospasm; Laryngotracheitis; Rhinitis; Rhinosinusitis; Wheezingbusiness
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Clinical effects of a Long-term Educational Program for Children with Asthma - Aironet®. A 1-yr randomized controlled trial

2009

Educational self-management programs for children with asthma have now become a routine feature in the management of the disease, as international guidelines underline. We designed this trial to find out whether Aironet, an educational program developed for children with asthma, influenced asthma severity and improved parents' knowledge of the disease. In a multicenter, prospective, randomized controlled trial we enrolled 123 children, 72 boys, mean age 8.78 yr (+/-2.33 s.d.), with intermittent or mild persistent asthma. Participants were randomly assigned to an education group, who received Aironet at baseline and 2 months later (60 children), or to a control group who did not (63 children…

MaleParentsSpirometryHealth Knowledge Attitudes Practicemedicine.medical_specialtyPediatricsHealth BehaviorImmunologyDiseaseSeverity of Illness Indexlaw.inventionPatient Education as TopicRandomized controlled triallawOutpatientsmedicineAnti-Asthmatic AgentHumansImmunology and AllergyAnti-Asthmatic AgentsChildSeverity of Illness Index; Outpatients; Self Care; Humans; Anti-Asthmatic Agents; Asthma; Child; Patient Education as Topic; Health Knowledge Attitudes Practice; Health Behavior; Program Evaluation; Parents; Female; MaleAsthmamedicine.diagnostic_testbusiness.industryRespiratory diseaseOutpatientmedicine.diseaseAsthmaSelf CareEl NiñoParentPediatrics Perinatology and Child HealthPhysical therapyFemaleHealth educationbusinessEducational programHumanProgram EvaluationPediatric Allergy and Immunology
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Assessing Repeatability and Reproducibility of Anterior Active Rhinomanometry (AAR) in Children

2020

AbstractBackgroundRepeatability and reproducibility are essential for clinicians for several purposes. Although discouraged, use of the Coefficient of Variation (CV) for assessing repeatability and reproducibility, rather than the Intraclass Correlation Coefficient (ICC), is still widespread. The aim of the present study was to highlight how using inappropriate indices may lead to misleading results, and this is done by simulation study and using real data on Anterior Active Rhinomanometry (AAR) in both healthy children and ones with rhinitis.MethodsA simulation study was carried out to highlight how using inappropriate indices could be misleading. Then a comparison was made between CV and …

MaleEpidemiologyIntraclass correlationCoefficient of variationHealth InformaticsRhinitis.03 medical and health sciences0302 clinical medicineMedicineHumans030212 general & internal medicineRepeatabilityChildChildren030304 developmental biologyRhinitisAnterior Active RhinomanometryNasal resistancelcsh:R5-9200303 health sciencesReproducibilityIntraclass Correlation Coefficientmedicine.diagnostic_testbusiness.industryReproducibility of ResultsGold standard (test)RepeatabilityRhinomanometryClinical PracticeCoefficient of Variationanterior active rhinomanometry; children; coefficient of variation; intraclass correlation coefficient; repeatability; rhinitisFemaleRhinomanometrylcsh:Medicine (General)businessNuclear medicineResearch Article
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Kawasaki disease: Guidelines of Italian Society of Pediatrics, part II - Treatment of resistant forms and cardiovascular complications, follow-up, li…

2018

Abstract This second part of practical Guidelines related to Kawasaki disease (KD) has the goal of contributing to prompt diagnosis and most appropriate treatment of KD resistant forms and cardiovascular complications, including non-pharmacologic treatments, follow-up, lifestyle and prevention of cardiovascular risks in the long-term through a set of 17 recommendations. Guidelines, however, should not be considered a norm that limits the treatment options of pediatricians and practitioners, as treatment modalities other than those recommended may be required as a result of peculiar medical circumstances, patient’s condition, and disease severity or individual complications.

MaleDrug ResistanceReviewCoronary Artery Disease030204 cardiovascular system & hematologySeverity of Illness IndexCoronary artery diseaseEfficacy0302 clinical medicineCardiovascular Diseasecoronary artery abnormalitiesChildCoronary artery abnormalitieSocieties MedicalPediatricAnti-Inflammatory Agents Non-Steroidallcsh:RJ1-570Immunoglobulins IntravenousSettore MED/38Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICACardiovascular DiseasesInnovative biotechnologieChild PreschoolPractice Guidelines as TopicFemaleRisk assessmentmedicine.drugHumanmedicine.medical_specialtypediatricsMucocutaneous Lymph Node SyndromeRisk AssessmentFollow-Up Studie03 medical and health sciencesinnovative biotechnologies030225 pediatricsDiabetes mellitusSeverity of illnessmedicineHumansIntensive care medicineIntravenous immunoglobulinAspirinKawasaki diseasebusiness.industryWarfarinlcsh:Pediatricsmedicine.diseasePersonalized medicineInfliximabAspirin; Child; Coronary artery abnormalities; Innovative biotechnologies; Intravenous immunoglobulin; Kawasaki disease; Personalized medicine;Immunoglobulins IntravenouPediatrics Perinatology and Child Healthperinatology and child healthKawasaki diseaseaspirin; child; coronary artery abnormalities; innovative biotechnologies; intravenous immunoglobulin; Kawasaki disease; personalized medicine; pediatrics perinatology and child healthbusinessFollow-Up Studies
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Management of chronic urticaria in children: a clinical guideline

2019

Abstract The aim of this guidance is to provide recommendations to clinicians and other interested parties on chronic urticaria in children. The Italian Society for Pediatrics (SIP), the Italian Society for Allergy and Immunology (SIAIP), the Italian Society for Pediatric dermatology (SIDerP) convened a multidisciplinary panel that prepared clinical guidelines for diagnosis and management of chronic urticaria in childhood. Key questions on epidemiology, natural history, diagnosis, and management were developed. The literature was systematically searched and evaluated, recommendations were rated and algorithms for diagnosis and treatment were developed. The recommendations focus on identific…

medicine.medical_specialtyUrticariaAllergyReviewPathogenesisOmalizumabOmalizumab03 medical and health sciences0302 clinical medicinePathogenesiMultidisciplinary approach030225 pediatricsEpidemiologymedicineHumans030212 general & internal medicineAngioedemaPediatric dermatologyChildChildrenChronic urticariaPediatricAngioedemabusiness.industrylcsh:RJ1-570lcsh:PediatricsGeneral MedicineGuidelineChronic urticariaChronic spontaneous urticariaSettore MED/38ManagementNatural historyInducible uricariaItalyFamily medicineTherapymedicine.symptombusinessmedicine.drugItalian Journal of Pediatrics
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Kawasaki disease: guidelines of the Italian Society of Pediatrics, part I - definition, epidemiology, etiopathogenesis, clinical expression and manag…

2018

Abstract The primary purpose of these practical guidelines related to Kawasaki disease (KD) is to contribute to prompt diagnosis and appropriate treatment on the basis of different specialists’ contributions in the field. A set of 40 recommendations is provided, divided in two parts: the first describes the definition of KD, its epidemiology, etiopathogenetic hints, presentation, clinical course and general management, including treatment of the acute phase, through specific 23 recommendations. Their application is aimed at improving the rate of treatment with intravenous immunoglobulin and the overall potential development of coronary artery abnormalities in KD. Guidelines, however, should…

MalePediatricsReviewPediatricsSeverity of Illness Index0302 clinical medicineRetrospective StudieEpidemiology030212 general & internal medicineDisease management (health)Coronary artery abnormalitieChildrenSocieties MedicalRandomized Controlled Trials as TopicPediatriclcsh:RJ1-570Disease ManagementImmunoglobulins IntravenousGeneral MedicinePrognosisSettore MED/38Treatment OutcomeSettore MED/38 - PEDIATRIA GENERALE E SPECIALISTICAItalyMeta-analysisAcute DiseasePractice Guidelines as TopicDisease ProgressionFemaleCoronary artery abnormalitiesAspirin; Children; Coronary artery abnormalities; Intravenous immunoglobulin; Kawasaki disease;Humanmedicine.medical_specialtyPrognosiMucocutaneous Lymph Node SyndromeRisk Assessment03 medical and health sciences030225 pediatricsSeverity of illnessmedicineHumansRisk factorIntravenous immunoglobulinRetrospective Studiesaspirin; children; coronary artery abnormalities; intravenous immunoglobulin; Kawasaki disease; pediatrics perinatology and child healthAspirinKawasaki diseasebusiness.industrylcsh:PediatricsRetrospective cohort studymedicine.diseaseImmunoglobulins IntravenouPediatrics Perinatology and Child Healthperinatology and child healthKawasaki diseaseDifferential diagnosisbusiness
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Consensus statement of the Italian society of pediatric allergy and immunology for the pragmatic management of children and adolescents with allergic…

2020

AbstractThe COVID-19 pandemic has surprised the entire population. The world has had to face an unprecedented pandemic. Only, Spanish flu had similar disastrous consequences. As a result, drastic measures (lockdown) have been adopted worldwide. Healthcare service has been overwhelmed by the extraordinary influx of patients, often requiring high intensity of care. Mortality has been associated with severe comorbidities, including chronic diseases. Patients with frailty were, therefore, the victim of the SARS-COV-2 infection. Allergy and asthma are the most prevalent chronic disorders in children and adolescents, so they need careful attention and, if necessary, an adaptation of their regular…

AllergyReview030207 dermatology & venereal diseasesSettore MED/38 - Pediatria Generale E Specialistica0302 clinical medicineCOVID-19 ; Child ; Pandemic ; Allergy ; Immunologic disease ; Asthma ; AdolescentPandemicViral030212 general & internal medicineDisease management (health)ChildSocieties MedicalCOVID-19; pandemic; child; adolescent; allergy; asthma; immunologic diseaseIncidence (epidemiology)lcsh:RJ1-570Disease ManagementGeneral MedicineAtopic dermatitisSettore MED/38Adolescent; Allergy; Asthma; Child; COVID-19; Immunologic disease; Pandemic; Adolescent; COVID-19; Child; Coronavirus Infections; Decision Making; Humans; Italy; Pneumonia Viral; Pragmatic Clinical Trials as Topic; SARS-CoV-2; Allergy and Immunology; Betacoronavirus; Consensus; Disease Management; Pandemics; Societies MedicalItalyLatex allergyAdolescent; Allergy; Asthma; COVID-19; Child; Immunologic disease; PandemicCoronavirus InfectionsHumanTelemedicineConsensusAdolescentDecision MakingPneumonia ViralConsensuBetacoronavirus03 medical and health sciencesMedicalAllergy and ImmunologyPragmatic Clinical Trials as TopicmedicineHumansRisk factorPandemicsPandemicBetacoronavirubusiness.industryCoronavirus InfectionSARS-CoV-2COVID-19lcsh:PediatricsPneumoniamedicine.diseaseAsthmaAdolescent; Allergy; Asthma; Child; COVID-19; Immunologic disease; PandemicImmunologic diseaseImmunologySocietiesbusinessRare disease
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Severe asthma features in children: A case–control online survey

2016

Background Very few studies have explored the distinguishing features of severe asthma in childhood in Europe, and only one study was conducted in Southern Europe. The aim of this study was to provide a detailed characterization of children with severe asthma treated in specialized pediatric asthma centers across Italy. Methods We conducted a web-based data collection of family, environmental, clinical and laboratory characteristics of 41 patients aged 6–17 years with severe asthma, defined according to the recent guidelines of the European Respiratory Society and the American Thoracic Society, and 78 age-matched peers with non-severe persistent asthma. The patients have been enrolled from …

Quality of lifeMalePediatricsmedicine.medical_specialtyAllergyAdolescentmacromolecular substancesSeverity of Illness IndexPediatricsAtopy03 medical and health sciences0302 clinical medicineQuality of lifeSurveys and QuestionnairesSeverity of illnessmedicineHumansAsthma; Atopy; Children; Lung function; Quality of life; Pediatrics Perinatology and Child Health030212 general & internal medicineChildChildrenAsthmaRespiratory Function Testbusiness.industryAtopyResearchCase-control studyAsthma; Atopy; Children; Lung function; Quality of life; Adolescent; Asthma; Case-Control Studies; Child; Female; Humans; Italy; Male; Quality of Life; Respiratory Function Tests; Severity of Illness Index; Surveys and Questionnaires; Pediatrics Perinatology and Child HealthOdds ratioAdolescent; Asthma; Case-Control Studies; Child; Female; Humans; Italy; Male; Quality of Life; Respiratory Function Tests; Severity of Illness Index; Surveys and QuestionnairesPerinatology and Child Healthmedicine.diseaseAsthmaLung functionrespiratory tract diseasesRespiratory Function Tests030228 respiratory systemItalyCase-Control StudiesExhaled nitric oxidePediatrics Perinatology and Child HealthFemalebusinessCase-Control StudieHuman
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Cabbage and fermented vegetables: from death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19

2021

International audience; Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage have been associated with low death rates in European countries. SARS-CoV-2 binds to its receptor, the angiotensin-converting enzyme 2 (ACE2). As a result of SARS-CoV-2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT1 R) axis associated with oxidative stress. This leads to insulin resistance …

ARIA groupAntioxidantMediterranean dietmedicine.medical_treatmentBrassicasulforaphaneMESH: Angiotensin-Converting Enzyme 2ReviewcabbageAntioxidants0302 clinical medicine10183 Swiss Institute of Allergy and Asthma ResearchVegetableskimchiFood sciencekimči0303 health sciencesMESH: NF-E2-Related Factor 23. Good healthAngiotensin-converting enzyme 22723 Immunology and Allergyfermentirana zelenjavaMESH: EcologyKeywords: Angiotensin converting enzyme 2NF-E2-Related Factor 2KEAP1-NRF2 SYSTEMImmunologyReviewsBrassicaNRF203 medical and health sciencesudc:578:635.34:663.15:COVID‐19angiotensin-converting enzyme 2CorrespondenceHumansMESH: SARS-CoV-2LactobacilluINTERMITTENT HYPOXIA2403 ImmunologyScience & TechnologyMESH: HumansAngiotensin II receptor type 1koronavirusMESH: Antioxidantsmedicine.disease030228 respiratory systemchemistryFermentationAllergymedicine.disease_causechemistry.chemical_compoundLINKING GUT MICROBIOTALactobacillalesLactobacillusImmunology and AllergyMESH: COVID-19Angiotensin converting enzyme 2030212 general & internal medicineOXIDATIVE STRESS[SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/AllergologyKeywords: Angiotensin converting enzyme 2; COVID-19; Lactobacillus; cabbage; diet; fermented vegetable; kimchi; sulforaphane.angiotensin-converting enzyme 2; cabbage; COVID-19; diet; fermented vegetable; kimchi; Lactobacillus; sulforaphane2. Zero hungerFOODSEcologyLactobacillalesMortality rate10177 Dermatology ClinicMEDITERRANEAN DIET1107 ImmunologyLife Sciences & Biomedicinefermented vegetable610 Medicine & healthSettore MED/10 - Malattie Dell'Apparato RespiratorioBiologyMESH: FermentationMESH: Gastrointestinal MicrobiomeInsulin resistanceMESH: DietDownregulation and upregulationmedicine030304 developmental biologySARS-CoV-2COVID-19MESH: BrassicaCOVID-19; Lactobacillus; angiotensin-converting enzyme 2; cabbage; diet; fermented vegetable; kimchi; sulforaphane; Angiotensin-Converting Enzyme 2; Antioxidants; COVID-19; Diet; Ecology; Gastrointestinal Microbiome; Humans; Lactobacillales; NF-E2-Related Factor 2; Brassica; Fermentation; SARS-CoV-2; Vegetablesbiology.organism_classificationMESH: VegetablesDYSFUNCTIONDietGastrointestinal MicrobiomeLactobacillusMESH: Lactobacillalesangiotensin-converting enzyme 2 cabbage COVID-19 diet fermented vegetable kimchi Lactobacillus sulforaphanedietOxidative stressSulforaphane
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