NEUROFIBROMATOSI DI TIPO 1 ED IPOTIROIDISMO SUB-CLINICO DA TIROIDITE AUTOIMMUNE: DESCRIZIONE DI UN CASO IN ETA’ PEDIATRICA

Osmophobia in migraine classification: a multicentre study in juvenile patients.

Aims: This study was planned to investigate the diagnostic utility of osmophobia as criterion for migraine without aura (MO) as proposed in the Appendix (A1.1) of the International Classification of Headache Disorders (ICHD-II, 2004). Methods: We analysed 1020 patients presenting at 10 Italian juvenile headache centres, 622 affected by migraine (M) and 328 by tension-type headache (TTH); 70 were affected by headache not elsewhere classified (NEC) in ICHD-II. By using a semi-structured questionnaire, the prevalence of osmophobia was 26.9%, significantly higher in M than TTH patients (34.6% vs 14.3%). Results: Osmophobia was correlated with: (i) family history of M and osmophobia; and (ii) o…

Aortic pulse wave velocity in children with migraine: a case control study

Background: Migraine has been associated with increased risk of cardiovascular (CV) accident like angina and myocardial infarction(1) . Vascular changes in migraineur traditionally may prevail in cranial blood district, but more likely it is a generalized vascular phenomenon.(2) Previous studies showed an increased aortic pulse wave velocity (aPWV), a direct measure of aortic stiffness and an independent predictor of stroke and CV disease, in young and middle-aged migraineurs(3) Here we hypothesized that, if associated with the pathogenetic bases of the disease, increased aPWV should be appreciable also in migraineurs children. Materials and Methods: : We studied 10 children with migraine w…

The red ear syndrome and migraine: the role of the parasympathetic system in a complex and intriguing clinical association

Background and aims: The red ear syndrome (RES) is a rare syndrome characterized by burning pain and cutaneous erythema in the ear. It is probably due to an autonomic dysfunction, because of a hypofunction of sympathetic and/or a hyperactivity of parasympathetic control. We have previously described an intriguing association with migraine. In the present study, we have investigated the pathophysiological links between the RES and the clinical features of migraine, and pointed out the crucial role of the parasympathetic system. Methods: A total of 172 young migraine sufferers (92 M and 80 F, aged 4–17 years) underwent a clinical and instrumental evaluation. A semi-structured interview about …