Gustatory evoked potentials activity and fatty taste

International audience; Introduction: Gustatory evoked potentials (GEP), detected in response to an intermittent stimulation of the gustatory receptors by a primary flavor, are a reliable and safe record of the human gustatory function. We previously highlighted the modifications of GEP in response to saccharose stimulation by the concentration of the saccharose solution and its hedonic sensation. Fatty taste might be considered as the sixth primary flavor. We aimed to demonstrate that GEP in response to fatty taste stimulation do exist, and to compare these GEP with the GEP in response to saccharose and salty taste.Methods: Healthy and voluntary male subjects were included. Each subject un…

Dual role of acyl-coa binding protein in the hypothalamus: regulator of astrocyte fatty acid metabolism and gliotransmitter targeting pomc neurons

La liste des auteurs est incomplète.; absent

Gustatory evoked cortical activity in humans in response to saccharose stimuli

National audience

Influence du liraglutide (analogue du GLP-1) sur les caractéristiques hédoniques de la prise alimentaire et les performances gustatives, chez les patients diabétiques de type 2

Reactive oxygen species and nutrient sensing

http://www.diabetes.org.uk/Diabetes-UK-Professional-Conference/; International audience

Gustatory evoked potentials and cerebral control of food intake in obese subjects (PEGASE study)

Cortical taste activity in response to sucrose and sweeteners solutions: a study using gustatory evoked potential

Introduction: Sweeteners are widespread in overweight or diabetic patients because of their high sweetening power and their light effect on glycaemia. Sweeteners effects on cortical activity, reflecting both cortical analysis and gustatory signalization pathway, are not well known. We observed previously that gustatory evoked potentials (GEPs) in response to sucrose varied in latency and/or in amplitude with sucrose concentration of the solution, the pleasantness of taste and the feeding status. The aim was to compare the gustatory cortical activity by recording GEPs in response to sucrose, aspartame and stevia solutions.Methods: Twenty healthy non-smoker adult volunteers were included (mea…

Treatment by GLP-1 agonist modulates hedonic response to food and taste sensitivity in type 2 diabetes

Context: Besides their potential action in the treatment of type 2 diabetes mellitus (T2DM), GLP-1 analogues have been shown to decrease satiety and food intake. However, little is known about their effects on food hedonic and taste perceptions. Objective: The objective of the study was to investigate the impact of GLP-1 analogue Liraglutide on the liking and wanting component of the food reward system as well as on taste sensitivity in T2DM patients. . Research design and methods: Thirty T2DM patients were studied before and after 3 months of daily Liraglutide treatment (1.2 mg). In each trial, blood samples were collected and body mass composition was analyzed by dual-energy X-ray absorpt…

Biology of food intake [Session II: Promising fields in the science of nutrition / Food dedicated to human health]

Présentation confidentielle; absent

Influence des expériences sensorielles précoces sur le comportement alimentaire

Brain Control of Plasma Cholesterol Involves Polysialic Acid Molecules in the Hypothalamus

IF 3.566; International audience; The polysialic acid (PSA) is a large glycan that is added to cell-surface proteins during their post-translational maturation. In the brain, PSA modulates distances between cells and controls the plasticity of the nervous system. In the hypothalamus, PSA is involved in many aspects of energy balance including food intake, osmoregulation, circadian rhythm, and sleep. In this work, we investigated the role of hypothalamic PSA in the regulation of plasma cholesterol levels and distribution. We report that HFD consumption in mice rapidly increased plasma cholesterol, including VLDL, LDL, and HDL-cholesterol. Although plasma VLDL-cholesterol was normalized withi…

Impact du diabete de type 2 sur l'etat de type “dépressif” chez la souris

La liste des auteurs est incomplète.; absent