0000000001242731

AUTHOR

Barbara A. Sorg

showing 1 related works from this author

Impact of Perineuronal Nets on Electrophysiology of Parvalbumin Interneurons, Principal Neurons, and Brain Oscillations: A Review

2021

Perineuronal nets (PNNs) are specialized extracellular matrix structures that surround specific neurons in the brain and spinal cord, appear during critical periods of development, and restrict plasticity during adulthood. Removal of PNNs can reinstate juvenile-like plasticity or, in cases of PNN removal during early developmental stages, PNN removal extends the critical plasticity period. PNNs surround mainly parvalbumin (PV)-containing, fast-spiking GABAergic interneurons in several brain regions. These inhibitory interneurons profoundly inhibit the network of surrounding neurons via their elaborate contacts with local pyramidal neurons, and they are key contributors to gamma oscillations…

0301 basic medicineContext (language use)Neurosciences. Biological psychiatry. NeuropsychiatryReviewInhibitory postsynaptic potentialmemory03 medical and health sciencesCellular and Molecular Neuroscience0302 clinical medicineparvalbuminmedicinebiologyPerineuronal netLong-term potentiationCell BiologySpinal cordElectrophysiologyperineuronal nets (PNNs)030104 developmental biologymedicine.anatomical_structurenervous systemplasticityoscillationsbiology.proteinGABAergicNeuroscience030217 neurology & neurosurgeryParvalbuminRC321-571NeuroscienceFrontiers in Synaptic Neuroscience
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