0000000001246113

AUTHOR

Lynnsey M. Hamilton

showing 1 related works from this author

IFN-gamma-induced protein 10 is a novel biomarker of rhinovirus-induced asthma exacerbations

2007

BACKGROUND: Rhinovirus-induced acute asthma is the most frequent trigger for asthma exacerbations. OBJECTIVE: We assessed which inflammatory mediators were released from bronchial epithelial cells (BECs) after infection with rhinovirus and then determined whether they were also present in subjects with acute virus-induced asthma, with the aim to identify a biomarker or biomarkers for acute virus-induced asthma. METHODS: BECs were obtained from bronchial brushings of steroid-naive asthmatic subjects and healthy nonatopic control subjects. Cells were infected with rhinovirus 16. Inflammatory mediators were measured by means of flow cytometry with a cytometric bead array. Subjects with acute a…

RhinovirusExacerbationNF-κB Nuclear factor κBAnti-Inflammatory Agentsairway inflammationmedicine.disease_causeDexamethasoneImmunology and AllergyChemokine CCL5LungRV-16 Rhinovirus 16Cells CulturedLR Likelihood ratioRespiratory diseaseMiddle AgedFlow Cytometrymedicine.anatomical_structureBiomarker (medicine)medicine.symptomRhinovirusChemokines CXCmedicine.drugAdultAdolescentImmunologyInflammationIFN gammaArticlemedicineHumansDexamethasoneAgedAsthmaPicornaviridae InfectionsInterleukin-6Tumor Necrosis Factor-alphabusiness.industryInterleukin-8BEC Bronchial epithelial cellEpithelial CellsTCID50 Tissue culture infectious dose 50%medicine.diseaseAsthmarespiratory tract diseasesChemokine CXCL10ImmunologyIP-10 IFN-γ–induced protein 10businessBiomarkersRespiratory tract
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