0000000001248759

AUTHOR

Daniela Bender

showing 1 related works from this author

Regulation of the Transferrin Receptor Recycling in Hepatitis C Virus-Replicating Cells

2020

After binding of its ligand transferrin, the transferrin receptor (TfR) is internalized via early endosomes. Ligand and receptor can be recycled. α-Taxilin was identified as an essential factor for TfR recycling. Apart from its role for iron uptake, TfR is a coreceptor for hepatitis C virus (HCV) infection. In HCV-replicating cells, the amount of a-taxilin is decreased. This study aims to investigate the effect of decreased α-taxilin levels in HCV-replicating cells on recycling of TfR, its amount on the cell surface, on iron uptake, and the impact of a disturbed TfR recycling on HCV superinfection exclusion. TfR amount and localization were determined by CLSM and surface biotinylation. α-ta…

hepatitis C virus0301 basic medicineEndosomemedia_common.quotation_subjectTransferrin receptorSuperinfection exclusionCell and Developmental Biology03 medical and health sciences0302 clinical medicineiron metabolismInternalizationReceptorlcsh:QH301-705.5iron metabolism ; transferrin receptor ; α-taxilin ; HCV superinfection ; Hepatitis C ; hepatitis C virusOriginal Researchmedia_commonchemistry.chemical_classificationα-taxilinHCV superinfectionvirus diseasesCell Biologytransferrin receptorLigand (biochemistry)Cell biology030104 developmental biologylcsh:Biology (General)chemistryTransferrin030220 oncology & carcinogenesisIntracellularDevelopmental BiologyFrontiers in Cell and Developmental Biology
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