0000000001249671

AUTHOR

Renata Pavlič

showing 5 related works from this author

Pyrithione-based ruthenium complexes as inhibitors of aldo-keto reductase 1C enzymes and anticancer agents.

2016

Four ruthenium complexes of clinically used zinc ionophore pyrithione and its oxygen analog 2-hydroxypyridine N-oxide were prepared and evaluated as inhibitors of enzymes of the aldo–keto reductase subfamily 1C (AKR1C). A kinetic study assisted with docking simulations showed a mixed type of inhibition consisting of a fast reversible and a slow irreversible step in the case of both organometallic compounds 1A and 1B. Both compounds also showed a remarkable selectivity towards AKR1C1 and AKR1C3 which are targets for breast cancer drug design. The organoruthenium complex of ligand pyrithione as well as pyrithione itself also displayed toxicity on the hormone-dependent MCF-7 breast cancer cell…

AKR1C1StereochemistryPyridinesIonophoreAldo-Keto Reductaseschemistry.chemical_elementAntineoplastic AgentsZincReductase010402 general chemistry01 natural sciencesRutheniumInorganic ChemistryCoordination ComplexesHumansCell Proliferationchemistry.chemical_classificationAldo-keto reductase010405 organic chemistryChemistryThiones0104 chemical sciencesRutheniumEnzymeDocking (molecular)MCF-7 CellsDalton transactions (Cambridge, England : 2003)
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CCDC 1444459: Experimental Crystal Structure Determination

2016

Related Article: Jakob Kljun, Maja Anko, Katja Traven, Maša Sinreih, Renata Pavlič, Špela Peršič, Žiga Ude, Elisa Esteve Codina, Jure Stojan, Tea Lanišnik Rižner, Iztok Turel|2016|Dalton Trans.|45|11791|doi:10.1039/C6DT00668J

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameterschloro-(p-cymene)-(pyridine-2-thiolato 1-oxide)-rutheniumExperimental 3D Coordinates
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CCDC 1444457: Experimental Crystal Structure Determination

2016

Related Article: Jakob Kljun, Maja Anko, Katja Traven, Maša Sinreih, Renata Pavlič, Špela Peršič, Žiga Ude, Elisa Esteve Codina, Jure Stojan, Tea Lanišnik Rižner, Iztok Turel|2016|Dalton Trans.|45|11791|doi:10.1039/C6DT00668J

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameterschloro-(p-cymene)-(pyridin-2-olato 1-oxide)-rutheniumExperimental 3D Coordinates
researchProduct

CCDC 1444456: Experimental Crystal Structure Determination

2016

Related Article: Jakob Kljun, Maja Anko, Katja Traven, Maša Sinreih, Renata Pavlič, Špela Peršič, Žiga Ude, Elisa Esteve Codina, Jure Stojan, Tea Lanišnik Rižner, Iztok Turel|2016|Dalton Trans.|45|11791|doi:10.1039/C6DT00668J

(dimethyl sulfoxide)-(pyridin-2-olato 1-oxide)-(147-trithionane)-ruthenium hexafluorophosphate chloroform solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
researchProduct

CCDC 1444458: Experimental Crystal Structure Determination

2016

Related Article: Jakob Kljun, Maja Anko, Katja Traven, Maša Sinreih, Renata Pavlič, Špela Peršič, Žiga Ude, Elisa Esteve Codina, Jure Stojan, Tea Lanišnik Rižner, Iztok Turel|2016|Dalton Trans.|45|11791|doi:10.1039/C6DT00668J

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates(dimethyl sulfoxide)-(pyridine-2-thiolato 1-oxide)-(147-trithionane)-ruthenium hexafluorophosphate
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