0000000001255098

AUTHOR

Rainer Misgeld

showing 2 related works from this author

Metal NHC Complexes with Naphthalimide Ligands as DNA-Interacting Antiproliferative Agents

2017

Naphthalimide-based N-heterocyclic carbene (NHC) complexes of the type [(1,5-cyclooctadiene)(NHC)RhCl)] (4 a-c), [(p-cymene)(NHC)RuCl2 )] (5 a-c), and [(NHC)CuBr] (6 a-c) were synthesized and investigated as antiproliferative agents that target DNA. The cytotoxic effects were largely driven by the naphthalimide structure, which is a DNA-intercalating moiety. Regarding the metal center, the highest activities were observed with the rhodium complexes, and cytotoxic activity was significantly lower for the ruthenium derivatives. The stable coordination of the NHC ligands of selected complexes 4 b and 5 b in solution was confirmed, and their DNA binding properties were studied by UV/Vis spectro…

Circular dichroismStereochemistryIntercalation (chemistry)Molecular Conformationchemistry.chemical_elementApoptosisCrystallography X-RayLigands010402 general chemistry01 natural sciencesBiochemistryRhodiumMetalchemistry.chemical_compoundDrug StabilityCoordination ComplexesDrug DiscoveryHumansMoietyGeneral Pharmacology Toxicology and PharmaceuticsrutheniumCell ProliferationPharmacology010405 organic chemistryChemistryCircular DichroismOrganic ChemistryDNAnaphthalimideIntercalating Agentsanticancer agent0104 chemical sciencesRutheniumcarbeneNaphthalimidesSettore CHIM/03 - Chimica Generale E Inorganicacoppervisual_artrhodiumMCF-7 CellsMonoterpenesvisual_art.visual_art_mediumCymenesMolecular MedicineSpectrophotometry UltravioletHT29 CellsMethaneCarbeneDNAChemMedChem
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CCDC 1510249: Experimental Crystal Structure Determination

2017

Related Article: Wojciech Streciwilk, Alessio Terenzi, Rainer Misgeld, Corazon Frias, Peter G. Jones, Habil. Aram Prokop, Bernhard K. Keppler, Ingo Ott|2017|ChemMedChem|12|214|doi:10.1002/cmdc.201600557

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parametersdichloro-(1-(3-(13-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)propyl)-3-ethyl-23-dihydro-1H-imidazol-2-ylidene)-(1-isopropyl-4-methylbenzene)-ruthenium(ii)Experimental 3D Coordinates
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