0000000001259584

AUTHOR

Sutherland Michael

showing 2 related works from this author

Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies

2020

AbstractThere are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of …

MAPK/ERK pathwayARIA groupAllergy[SDV]Life Sciences [q-bio]NF-KAPPA-BdebelostReviewPharmacologyResveratrolPROTECTSchemistry.chemical_compound0302 clinical medicineRESPIRATORY SYNDROME CORONAVIRUSENDOPLASMIC-RETICULUM STRESSMedicine and Health SciencesImmunology and AllergyMedicineOXIDATIVE STRESSCOVID-19; Foods; Insulin resistance; Nrf2; Nutrients; Obesity; TRPA12. Zero hunger0303 health sciencesRESPIRATORYINSULIN-RESISTANCEMuscle cell proliferationSULFORAPHANE3. Good health[SDV] Life Sciences [q-bio]Foods030220 oncology & carcinogenesisSIGNALING PATHWAYSignal transductionLife Sciences & BiomedicinePulmonary and Respiratory MedicineNRF2 ACTIVATORSMUSCLE-CELL PROLIFERATIONImmunology610 Medicine & healthLung injurySettore MED/10 - Malattie Dell'Apparato RespiratorioTRPA1Nrf2ACUTE LUNG INJURY03 medical and health sciencesInsulin resistanceCOVID-19 Foods Insulin resistance Nrf2 Nutrients Obesity TRPA1udc:616.9odpornost proti inzulinuSULFORAPHANE PROTECTSObesityTranscription factorPI3K/AKT/mTOR pathway030304 developmental biologyScience & Technologybusiness.industrySARS-CoV-2foodCOVID-19Insulin resistanceNutrientsmedicine.diseasechemistryhranilaSYNDROME CORONAVIRUSbusinesshranaGREEN TEA
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Searches for Large-Scale Anisotropy in the Arrival Directions of Cosmic Rays Detected above Energy of $10^{19}$ eV at the Pierre Auger Observatory an…

2014

Spherical harmonic moments are well-suited for capturing anisotropy at any scale in the flux of cosmic rays. An unambiguous measurement of the full set of spherical harmonic coefficients requires full-sky coverage. This can be achieved by combining data from observatories located in both the northern and southern hemispheres. To this end, a joint analysis using data recorded at the Telescope Array and the Pierre Auger Observatory above 1019 eV is presented in this work. The resulting multipolar expansion of the flux of cosmic rays allows us to perform a series of anisotropy searches, and in particular to report on the angular power spectrum of cosmic rays above 1019 eV. No significant devia…

Ciencias FísicasAstronomyRaysAstrophysicsAstroparticle physics; Cosmic rays01 natural scienceslaw.inventionPierrelawAnisotropyTelescope010303 astronomy & astrophysicsHigh Energy Astrophysical Phenomena (astro-ph.HE)Physics[PHYS]Physics [physics]Energy[SDU.ASTR.HE]Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE]Astrophysics::Instrumentation and Methods for Astrophysicsastroparticle physicRadiación cósmicaAugerCosmicArrivalComputingMethodologies_DOCUMENTANDTEXTPROCESSINGFísica nuclearAstrophysics - High Energy Astrophysical PhenomenaAstrophysics - Instrumentation and Methods for AstrophysicsCIENCIAS NATURALES Y EXACTASHigh[PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE][PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM]Astrophysics::High Energy Astrophysical PhenomenaFOS: Physical sciencesCosmic raySURFACE DETECTORICECUBETelescopeAIR-SHOWER ARRAYDirectionscosmic rays0103 physical sciencesInstrumentation and Methods for Astrophysics (astro-ph.IM)Cosmic raysCiencias ExactasPierre Auger ObservatorySPECTRUM010308 nuclear & particles physicsArraySpectral densitySpherical harmonicsFísicaAstronomy and AstrophysicsASTROFÍSICAUltra[SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM]AstronomíaDipoleRESOLUTIONSpace and Planetary ScienceExperimental High Energy PhysicsQuadrupoleObservatoryAstroparticle physics[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
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