Author: Shengwei Wei

0000000001261942

AUTHOR

Shengwei Wei

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Cytotoxicity of Artesunic Acid Homo- and Heterodimer Molecules toward Sensitive and Multidrug-Resistant CCRF-CEM Leukemia Cells

2010

A novel approach to circumvent multidrug resistance is hybridization of natural products in dimers. We analyzed homodimers of two artesunic acid molecules and heterohybrids of artesunic acid and betulin in human CCRF-CEM and multidrug-resistant P-glycoprotein-overexpressing CEM/ADR5000 leukemia cells. Multidrug-resistant cells were not cross-resistant to the novel compounds. Collateral sensitivity was observed for artesunic acid homodimer. Artesunic acid and artesunic acid homodimer induced G0/G1 cell cycle arrest, apoptosis, and formation of reactive oxygen species.

Spectrometry Mass Electrospray IonizationMagnetic Resonance SpectroscopyCell SurvivalApoptosischemistry.chemical_compoundCell Line TumorDrug DiscoverymedicineHumansCytotoxicitychemistry.chemical_classificationReactive oxygen speciesFormazansLeukemiaBetulinCell CycleSuccinatesCell cycleFlow Cytometrymedicine.diseaseArtemisininsTriterpenesMultiple drug resistanceLeukemiachemistryBiochemistryDrug Resistance NeoplasmCell cultureApoptosisMolecular MedicineReactive Oxygen SpeciesJournal of Medicinal Chemistry

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PEPhysical Sciences and Engineering
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