0000000001267083

AUTHOR

Angelo Minucci

0000-0002-0833-4334

showing 1 related works from this author

Medullary Thyroid Carcinoma With Exon 2 p.L56M RET Variant: Clinical Particular Features in Two Patients

2018

RET (REarranged during Transfection) proto-oncogene variants are essential for the development of familial and sporadic forms of medullary thyroid carcinoma (MTC). The most frequent variants are usually located in exons 10, 11, and 13 through 16 of the RET gene. We report two cases of apparently sporadic MTC associated with the variant in exon 2 of RET gene. Patient 1, a 62-year old man who had undergone adrenalectomy for a 5 cm pheochromocytoma, was screened for type 2 multiple endocrine neoplasia (MEN 2) which showed elevated basal and post-intravenous calcium gluconate calcitonin levels. A fine needle aspiration biopsy (FNAB) confirmed the suspicion of MTC. The patient underwent total th…

Pathologymedicine.medical_specialtyendocrine systemMedullary cavityendocrine system diseasesEndocrinology Diabetes and Metabolism030209 endocrinology & metabolismCase ReportL56M; Medullary thyroid carcinoma; MEN2; Pheochromocytoma; RET; Endocrinology Diabetes and Metabolismlcsh:Diseases of the endocrine glands. Clinical endocrinologyThyroid carcinomaPheochromocytoma03 medical and health sciences0302 clinical medicineEndocrinologymedullary thyroid carcinomaBiopsymedicineMultiple endocrine neoplasialcsh:RC648-665medicine.diagnostic_testbusiness.industrySettore MED/13 - ENDOCRINOLOGIAHyperplasiamedicine.diseasepheochromocytomaDiabetes and MetabolismFine-needle aspirationMEN2Calcitonin030220 oncology & carcinogenesisbusinessRETL56MFrontiers in Endocrinology
researchProduct